This journal provides immediate open access to its content on the principle that making research freely available to the public.This multicultural study aimed at examining moodchange of English, French and Chinese speaking immigrants in Ottawa and Gatineau, Canada, and identifying demographic factors that impact the change. 810 immigrants of English, French and Chinese speaking sub-groupswere recruited by purposive-sampling. Using self-reports, respondents answered questions regarding moodchange (moodstatus change and mood belief change) and demography in Multicultural Lifestyle Change Questionnaire of English, French or Chinese version. Data were analyzed statistically for the different immigrant sub-groups. Immigrants of different gender, language and category sub-groups exhibited different Mood Change Rates, Mood Improving Rates, Mood Declining Rates and MoodBelief Change Rates. There was no statistical difference between the ratesof immigrant subgroups. Mood Change (MoodStatus Change + MoodBelief Change) was correlated positively with Mother Tongue and negatively with Speaking Languages. MoodStatusChange was negatively correlated with Marital Status and Highest Level of Education. Mother Tongue, Speaking Languages and Highest Level of Education significantly impacted MoodChange (MoodStatus Change + MoodBelief Change).Marital Status and Highest Level of Education significantly influenced MoodStatus Change. Immigrants of different sub-groups in Canada experience ddifferent mood changes. Marital Status and Highest Level of Educationweremain factors impactingMoodStatus Change. Mother Tongue and Speaking Languages wereprincipal factors influencing Mood Belief Change. Culture was an important factor contributingMoodChange. Acculturation could impact MoodStatus Change andMood Belief Change. Data of immigrant mood change can provide evidence for health policy-making and policy-revising in Canada