Long-Term Monitoring of Post-Stroke Plasticity After Transient Cerebral Ischemia in Mice Using In Vivo and Ex Vivo Diffusion Tensor MRI

de Crespigny, A.J; D’Arceuil, H; Granziera, C; Magistretti, P.J; Sorensen, A.G; Zai, L

Long-Term Monitoring of Post-Stroke Plasticity After Transient Cerebral Ischemia in Mice Using In Vivo and Ex Vivo Diffusion Tensor MRI

Authors: A.J de Crespigny
H D’Arceuil
C Granziera
P.J Magistretti
A.G Sorensen
L Zai
Publication date: 1 January 2007
Publisher: Bentham Science Publishers Ltd.
Doi

Abstract

We used a murine model of transient focal cerebral ischemia to study: 1) in vivo DTI long-term temporal evolution of the apparent diffusion coefficient (ADC) and diffusion fractional anisotropy (FA) at days 4, 10, 15 and 21 after stroke 2) ex vivo distribution of a plasticity-related protein (GAP-43) and its relationship with the ex vivo DTI characteristics of the striato-thalamic pathway (21 days)