These viruses should be included in the differential diagnosis of febrile disease

Berk, Pamela

Danziger-Isakov, Lara

Goldfarb, Johanna

Gowans, Kate

Kohn, Debra

Pellett, Philip E.

Sabella, Camille

Wang, Fu-Zhang

Worley, Sarah

Yee-Guardino, Stephanie

Yen-Lieberman, Belinda

Emerging Infectious Diseases

English

PubMed

We conducted a cross-sectional study of β-herpesviruses in febrile pediatric oncology patients (n = 30), with a reference group of febrile pediatric solid-organ transplant recipients (n = 9). One (3.3%) of 30 cancer patients and 3 (33%) of 9 organ recipients were PCR positive for cytomegalovirus. Four (13%) of 30 cancer patients and 3 (33%) of 9 transplant recipients had human herpesvirus 6B (HHV-6B) DNAemia, which was more common within 6 months of initiation of immune suppression (4 of 16 vs. 0 of 14 cancer patients; p = 0.050). HHV-6A and HHV-7 were not detected. No other cause was identified in children with HHV-6B or cytomegalovirus DNAemia. One HHV-6B–positive cancer patient had febrile disease with concomitant hepatitis. Other HHV-6B–positive children had mild “viral” illnesses, as did a child with primary cytomegalovirus infection. Cytomegalovirus and HHV-6B should be included in the differential diagnosis of febrile disease in children with cancer

Stephanie Yee-Guardino

Kate Gowans

Belinda Yen-Lieberman

Pamela Berk

Debra Kohn

Fu-Zhang Wang

Lara Danziger-Isakov

Camille Sabella

Sarah Worley

Philip E. Pellett

Johanna Goldfarb

Directory of Open Access Journals

β-Herpesviruses in Febrile Children with Cancer

A randomized trial comparing ceftazidime alone with combination antibiotic therapy in cancer patients with fever and neutropenia.

Biologic properties of human herpesvirus 7 strain SB. Virus Res.

Characteristics and acquisition of human herpesvirus (HHV) 7 infections in relation to infection with HHV-6. J Infect Dis.

Clinical and laboratory features predicting a favorable outcome and allowing early discharge in cancer patients with low-risk febrile neutropenia: a literature review. J Hematother Stem Cell Res.

Comparison of molecular tests for detection and quantiﬁ cation of cell-associated cytomegalovirus DNA.

Cytomegalovirus and human herpesvirus 6 both cause viral disease after renal transplantation.

Cytomegalovirus infection in children with blood diseases. Acta Haematol Pol.

Cytomegalovirus infection in immunocompetent patients. Clin Infect Dis.

Detection of human herpesvirus 6 by reverse transcriptionPCR.

Differentiation and quantitation of human herpesviruses 6A, 6B and 7 by real-time PCR. J Virol Methods.

Evaluation of active human herpesvirus 6 infection by reverse transcription-PCR. J Med Virol. 2003;70:267–72. Address for correspondence:

Evaluation of risk prediction criteria for episodes of febrile neutropenia in children with cancer.

Exact unconditional sample sizes for the 2 × 2 binomial trial.

Fever in the pediatric and young adult patient with cancer. A prospective study of 1001 episodes. Medicine

Few but severe viral infections in children with cancer: a prospective RT-PCR and PCR-based 12-month study. Pediatr Blood Cancer.

Growth properties of human herpesvirus-6 strain Z29. J Virol Methods.

High incidence of Epstein-Barr virus, cytomegalovirus and human herpesvirus 6 infections in children with cancer.

High levels of human herpesvirus 6 DNA in peripheral blood leucocytes are correlated to platelet engraftment and disease in allogeneic stem cell transplant patients.

Human herpesvirus 6 DNA levels in cerebrospinal ﬂ uid due to primary infection differ from those due to chromosomal viral integration and have implications for diagnosis of encephalitis.

Human herpesvirus 6 viremia in bone marrow transplant recipients: clinical features and risk factors.

Human herpesvirus-6 and -7 infections in transplantation. Pediatr Transplant.

Human herpesvirus-6 DNA in the saliva of paediatric oncology patients and controls. J Med Virol.

Human herpesvirus-6 infection in children with cancer. Pediatr Hematol Oncol.

Human herpesvirus-6 infection in children. A prospective study of complications and reactivation.

Human herpesviruses 6 and 7 as potential pathogens after liver transplant: prospective comparison with the effect of cytomegalovirus.

Human herpesviruses 6 and 7.

Human herpesviruses 6A, 6B, and 7: immunobiology and host response. In:

Human herpesviruses-6, -7 and -8 in organ transplant recipients. Clin Microbiol Infect.

Inpatient versus outpatient management of lowrisk pediatric febrile neutropenia: measuring parents’ and healthcare professionals’ preferences.

Lippincott Williams and Wilkins;

Medical and non-medical barriers to outpatient treatment of fever and neutropenia in children with cancer. Pediatr Blood Cancer.

Primary cytomegalovirus infection in otherwise healthy adults with fever of unknown origin: a 3-year prospective survey.

Randomized comparison of antibiotics with and without granulocyte colony-stimulating factor in children with chemotherapy-induced febrile neutropenia: a report from the Children’s Oncology Group. Pediatr Blood Cancer.

Serological response of paediatric oncology patients to human herpesvirus-6. J Med Virol.

The importance of primary cytomegalovirus infection in childhood cancer.

The prevalence of chromosomally integrated human herpesvirus 6 genomes in the blood of UK blood donors.

Tipples GA. Human herpesviruses 6, 7, and 8. In:

Use of immunoglobulin G antibody avidity for differentiation of primary human herpesvirus 6 and 7 infections.

Viral infections in childhood leukemia.

Viral infections in neutropenia—current problems and chemotherapeutic control.

http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2570945

β-Herpesviruses in Febrile Children with Cancer

Abstract

Similar works

Full text

Available Versions

Directory of Open Access Journals