Persistent parasitemia despite dramatic reduction in malaria incidence after 3 rounds of indoor residual spraying in Tororo, Uganda.

Abstract

Background:Indoor residual spraying of insecticide (IRS) has been associated with reductions in the incidence of malaria, but its impact on malaria parasitemia is unclear. Methods:We followed 469 participants from August 2011 to May 2016 in Tororo, Uganda, a historically high malaria transmission setting. Three rounds of IRS with bendiocarb were implemented from December 2014 to December 2015. Symptomatic malaria episodes were identified by passive surveillance. Parasitemia was identified by active surveillance every 1-3 months using microscopy and P.falciparum-specific loop-mediated isothermal amplification. Results:IRS was associated with a significant decline in the incidence of symptomatic malaria irrespective of age (episodes per person per year reduced from 3.98 to 0.13 in children <5 years, 2.30 to 0.15 in children 5 - 10 years, and 0.41 to 0 in adults, p<0.001 for all). IRS significantly reduced the prevalence of parasitemia, however, the prevalence remained high (58.5% to 11.3% in children <5, 73.3% to 23.7% in children 5 - 10 years, and 52.2% to 15.4% in adults, p<0.001 for all). Discussion:Although IRS was associated with significant reductions in the incidence of malaria and prevalence of parasitemia, a proportion of the population remained parasitemic, providing a potential reservoir for malaria transmission