Browning, LM

Chatfield, M

Dixon, AK

Jebb, SA

Mugridge, O

Prentice, AM

LSHTM Research Online

LSHTM Research OnlineMugridge, O; Browning, LM; Chatfield, M; Dixon, AK; Prentice, AM; Jebb, SA; (2010) Measur-ing abdominal and visceral adipose tissue: comparison of data from simpler techniques with MRI.[Conference or Workshop Item] https://doi.org/10.1017/S0029665110001461Downloaded from: http://researchonline.lshtm.ac.uk/4654282/DOI: https://doi.org/10.1017/S0029665110001461Usage Guidelines:Please refer to usage guidelines at https://researchonline.lshtm.ac.uk/policies.html or alternativelycontact researchonline@lshtm.ac.uk.Available under license: Copyright the publishershttps://researchonline.lshtm.ac.ukWinter Meeting, 15 December 2009, Food supply and quality in a climate-changed worldMeasuring abdominal and visceral adipose tissue: comparison of datafrom simpler techniques with MRIO. Mugridge1, L. M. Browning1, M. Chatfield1, A. K. Dixon2, A. M. Prentice3 and S. A. Jebb11MRC Human Nutrition Research, Fulbourn Road, Cambridge CB1 9NL, UK, 2Department of Radiology,Cambridge University Hospitals NHS Foundation Trust, Addenbrooke’s Hospital, Hills Road, Cambridge CB2 2QQ, UKand 3MRC International Nutrition Group, London School of Hygiene and Tropical Medicine, Keppel Street,London WC1E 7HT, UKThe relationship between increasing body mass index (BMI) and an increased risk of morbidity and premature mortality is well estab-lished(1). However, attention is now focused on the amount of fat and its distribution within the body, with visceral adipose tissue (VAT)more strongly associated with metabolic risk than subcutaneous abdominal adipose tissue (SAAT)(2). Accordingly there is a need forsimple techniques that can discriminate regional fat.This study compared regional and total body fat measures obtained from simpler techniques, with the gold standard, MRI. One hundredand twenty participants, aged 18–79 years, stratified by gender and BMI were recruited, with measures made on two visits, within 7 d. Atthe first visit, weight, height, waist circumference (WC), dual energy x-ray absorptiometry (DXA) (Lunar Prodigy, GE Healthcare,Wisconsin, USA) and bioelectrical impedance (BIA) (Tanita Corp, Tokyo, Japan) measurements were made. Total and regional fatmeasurements were made with DXA (trunk and L2–L4), and with three BIA devices including the new abdominal BIA device (trunk and‘visceral fat level’). At the second visit, MRI was performed quantifying SAAT, VAT and total abdominal adipose tissue (TAAT) area.Data were analysed using Pearson’s correlation coefficients (Table 1).Table 1. The relationship between simpler and MRI measurementsVAT SAAT TAATMen Women Men Women Men WomenBMI 0.64 0.58 0.84 0.86 0.92 0.91WC 0.71 0.74 0.85 0.76 0.96 0.88DXA total body fat (%) 0.65 0.58 0.84 0.86 0.92 0.91DXA trunk fat (%) 0.69 0.63 0.77 0.82 0.89 0.89DXA abdominal fat (%) 0.70 0.62 0.77 0.83 0.90 0.90BIA (AB-140) ‘visceral fat level’ 0.65 0.64 0.87 0.86 0.94 0.92BIA (AB-140) trunk fat (%) 0.65 0.61 0.85 0.83 0.93 0.89BIA (AB-140) waist circumference 0.63 0.57 0.86 0.84 0.92 0.88BIA (BC-420) body fat (%) 0.71 0.65 0.76 0.71 0.90 0.81BIA (BC-420) ‘visceral fat level’ 0.80 0.64 0.64 0.47 0.87 0.61BIA (MC-180) body fat (%) 0.69 0.61 0.80 0.71 0.92 0.80BIA (MC-180) trunk fat (%) 0.64 0.81 0.80 0.65 0.89 0.71BIA (MC-180) ‘visceral fat level’ 0.82 0.61 0.67 0.45 0.90 0.58Most of the simpler measurements show better correlations with TAAT and SAAT than with VAT. DXA L2–L4 fat, WC and AB-140‘visceral fat level’ show similar relationships with TAAT. Of the three BIA devices, the specific abdominal BIA device (AB-140) showsstronger correlations with TAAT than the two whole-body BIA devices but none assessed VAT accurately.This study suggests that the simpler measures are better proxies for TAAT than VAT. BMI, WC and BIA methods provide similarcorrelations with MRI indices compared to the more complex DXA measure, suggesting the additional cost and radiation exposure to theparticipant associated with the DXA measurement may not be warranted in large-scale studies.1. Willett WC, Dietz WH & Colditz G (1999) N Engl J Med 341(6), 427–434.2. Fox CS, Massaro JM, Hoffmann U et al. (2007) Circulation 116, 39–48.Proceedings of the Nutrition Society (2010), 69 (OCE4), E337 doi:10.1017/S0029665110001461https://www.cambridge.org/core/terms. https://doi.org/10.1017/S0029665110001461Downloaded from https://www.cambridge.org/core. London School of Hygiene & Tropical Medicine, on 05 Sep 2019 at 14:07:36, subject to the Cambridge Core terms of use, available at

Measuring abdominal and visceral adipose tissue: comparison of data from simpler techniques with MRI

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Measuring abdominal and visceral adipose tissue: comparison of data from simpler techniques with MRI

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