BERTONI, B. W.

CERDEIRA, A. L.

DAMIÃO FILHO, C. F.

FRANÇA, S. C.

MORAES, R. M.

PEREIRA, A. M. S.

PEREIRA, P. S.

SALOMÃO, A. N.

English

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5th Oxford International Conference on the Science of Botanical« (ICSB), "Quality, Safety and Processing of Botanical Products"August 2 1 —24el' 2006, University. Mississippi.Sponsored by CFSAN/FDA and CS1R (Council of Scientific & Industrial Research) - IndiaGrowth Cunditions of Zeyheria man I an a Mart as a Source of Lapachol.B.W. Bertoni1; A.M.S, Pereira1: P.S. Pereira1; C.F. Damiao-FHho2; A.N. Salomao1;S.C. Françi ; R.M. Moraes3; AX. Cerdcira’1'University of Ribdrao Prcto, Av. Costabile Romano, 2201, Ribeirão Preto, S l\ 14.096-380, Brazil, \Sao Paulo State University, Rod. Paulo Castellanc s/n 14884-900, Jaboticabal, SP. Bray.il, '’National Center for Natural Products Research. The University or Mississippi, University, MS, 38655, USA, and ^Brazilian Department of Agriculture. Emhrapa/hnvironment, C.P. 69, Jaguariuna, SP, 13820-000, Brazil.Zeyheria montrma Man., is a species native to the savjnna region of central Brazil. Roois contain lapachol, a naphthoquinone with anii-cancer properties which is a procursor of JHupuchone. Like camptotliecin and lopotecan. fi-lapachone inhibits DNA lopoisomeirase I. Topoisomerasc inhibitors, including p-lapachone, are effective against several types of cancer, including lung, breast, colon and prostate cancers. Tin: use of P-lapachone in humans has been limited due to its toxicity. A new scmt synthetic analog 3-allyj-P-iapachone, however has lower toxicity in ccll culture and greater potential as anticanccr treatment. This study was conducted to evaluate lunachol content in Z. monuona and its potential for domestication as a specialty crop. Seed germination and li^ht condition studies were conducted to evaluate the conditions for propagation of the species and enhancement of lapacho! yield. Results huve shown that seed wing removal was beneficial to improve s>ccd germination and light was not a requirement for germination. Storage at room temperature decieascd germination Tram 90.2 to 30.5% after six monlhs. Different light intensities were evaluated for lapachol production, and roots from plantletá maintained under darkness• f Ito 200 uM in'" s of light produced 50 times more lapachol than those kept at 800 |iM lit'2 s '1, indicating that the content Of lapachol is enhanced under lower light intensities. It is desirable to »tow Z  Montana under shade conditions for lapachol production.P 11

Growth conditions of zeyheria montana mart as a source of lapachol.

http://www.alice.cnptia.embrapa.br/bitstream/doc/1032141/1/2006RA109.pdf

Growth conditions of zeyheria montana mart as a source of lapachol.

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