We conducted a cross-sectional study with 401 patients of type 1 diabetes mellitus treated with insulin glargine in Minas Gerais, Brazil. Health-related quality of life (HRQoL) was assessed using EQ-5D-3L and the Diabetes Quality of Life Measure. Our findings showed that a worse HRQoL was associated with a low level of education, self-perceived health reported as poor/very poor, being bedridden and not physically exercised, had seen a doctor more than four times in the past year before the interview, and had reported comorbidities and episodes of hypoglycemia