OBJECTIVE—Although glycemic levels are known to rise with normal aging, the nondiabetic A1C range is not age specific. We examined whether A1C was associated with age in nondiabetic subjects and in subjects with normal glucose tolerance (NGT) in two population-based cohorts

C. Driver

C. S. Fox

Carrera

D. M. Nathan

Davidson

Greco

Hashimoto

J. B. Meigs

Kabadi

KANNEL

Korn

L. Korenda

L. N. Pani

L. Sullivan

Little

Matyka

Meigs

MULKERRIN

Muntner

Nakashima

Nathan

Nuttall

R. B. D'Agostino

S. Chamany

Selvin

Simon

The DCCT Research Group

Vall  e Polneau

Wiener

Yang

Yates

English

PubMed

Crossref

Effect of Aging on A1C Levels in Individuals Without Diabetes: Evidence from the Framingham Offspring Study and the National Health and Nutrition Examination Survey 2001-2004

OBJECTIVE: Although glycemic levels are known to rise with normal aging, the nondiabetic A1C range is not age specific. We examined whether A1C was associated with age in nondiabetic subjects and in subjects with normal glucose tolerance (NGT) in two population-based cohorts. RESEARCH DESIGN AND METHODS: We performed cross-sectional analyses of A1C across age categories in 2,473 nondiabetic participants of the Framingham Offspring Study (FOS) and in 3,270 nondiabetic participants from the National Health and Nutrition Examination Survey (NHANES) 2001–2004. In FOS, we examined A1C by age in a subset with NGT, i.e., after excluding those with impaired fasting glucose (IFG) and/or impaired glucose tolerance (IGT). Multivariate analyses were performed, adjusting for sex, BMI, fasting glucose, and 2-h postload glucose values. RESULTS: In the FOS and NHANES cohorts, A1C levels were positively associated with age in nondiabetic subjects. Linear regression revealed 0.014- and 0.010-unit increases in A1C per year in the nondiabetic FOS and NHANES populations, respectively. The 97.5th percentiles for A1C were 6.0% and 5.6% for nondiabetic individuals aged <40 years in FOS and NHANES, respectively, compared with 6.6% and 6.2% for individuals aged ≥70 years (Ptrend < 0.001). The association of A1C with age was similar when restricted to the subset of FOS subjects with NGT and after adjustments for sex, BMI, fasting glucose, and 2-h postload glucose values. CONCLUSIONS: A1C levels are positively associated with age in nondiabetic populations even after exclusion of subjects with IFG and/or IGT. Further studies are needed to determine whether age-specific diagnostic and treatment criteria would be appropriate.National Institute's of Health National Heart, Lung and Blood
Institute’s Framingham Heart Study (N01-HC-25195); Boston University School of Medicine; American Diabetes Association Career Development Award; National Institute of Diabetes and Digestive and Kidney Diseases (K24 DK080140); Earl P. Charlton Fund for Innovative Diabetes Research; Institutional National Research Service Award (T32

Pani, Lydie N.

Korenda, Leslie

Meigs, James B.

Driver, Cynthia

Chamany, Shadi

Fox, Caroline S.

Sullivan, Lisa

D'Agostino, Ralph B.

Nathan, David M.

Boston University Institutional Repository (OpenBU)

Effect of Aging on A1C Levels in Individuals Without Diabetes

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Effect of Aging on A1C Levels in Individuals Without Diabetes: Evidence from the Framingham Offspring Study and the National Health and Nutrition Examination Survey 2001–2004

Effect of Aging on A1C Levels in Individuals Without Diabetes: Evidence from the Framingham Offspring Study and the National Health and Nutrition Examination Survey 2001–2004

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