Ahmad, Sajjad

Chen, Jern

Dwivedi, Rahul

Kaye, Stephen B

Romano, Vito

Spiteri, Natasha

Willoughby, Colin E

Yadav, Sohraab

Zheng, Yalin

Ophthalmology

Natasha Spiteri

Vito Romano

Yalin Zheng

Sohraab Yadav

Rahul Dwivedi

Jern Chen

Sajjad Ahmad

Colin E. Willoughby

Stephen B. Kaye

Crossref

Corneal Angiography for Guiding and Evaluating Fine-Needle Diathermy Treatment of Corneal Neovascularization

PurposeTo investigate the outcome of selective occlusion of the afferent vessel of corneal neovascular complexes (CoNVs), using angiographically guided fine-needle diathermy (FND).DesignRetrospective interventional case series.SubjectsPatients with CoNV unresponsive to topical steroid therapy.MethodsVisual acuity, color images, and fluorescein angiography and indocyanine green angiography were measured before and after FND with a minimum of 3 months of follow-up. The number of afferent vessels crossing the limbus, time to fluorescein leakage, area, and geometric properties of the CoNV were determined using an in-house automated program written in numerical computing language (MatLab R14; The MathWorks Inc., Natick, MA). The location of the afferent vessel was identified from the angiographic images and marked at the slit lamp using a needle to make a cut to the depth of the vessel. We then applied FND using an electrolysis needle.Main outcome measuresArea of CoNV.ResultsThirty patients underwent FND for CoNV that had not responded to treatment with topical steroids. The CoNV was associated with previous microbial keratitis (n = 26), intrastromal corneal ring segments (n = 2), ectodermal dysplasia (n = 1), and corneal choristoma (n = 1). Duration of CoNV was >6 months in 23 patients (77%), between 3 and 6 months in 3 patients (10%), and ConclusionsThe differentiation of afferent and efferent vessels using corneal angiography enables treatment to be selectively applied to the afferent vessels; there are usually 1 to 2 for each CoNV complex

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Corneal Angiography for Guiding and Evaluating Fine-Needle Diathermy Treatment of Corneal Neovascularization

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University of Liverpool Repository