Avalos, Javier

Baker, Scott E

Bauer, Diane

Benito, Ernesto P

Benoit, Isabelle

Braun, Edward L

Burger, Gertraud

Camino, Lola P

Canovas, David

Cerda-Olmedo, Enrique

Cheng, Jan-Fang

Corrochano, Luis M

de Vries, Ronald P

Dominguez, Angel

Elias, Marek

Eslava, Arturo P

Gabaldon, Toni

Garre, Victoriano

Glaser, Fabian

Grigoriev, Igor V

Grimwood, Jane

Gutierrez, Gabriel

Heitman, Joseph

Henrissat, Bernard

Herrera-Estrella, Alfredo

Horwitz, Benjamin A

Idnurm, Alexander

Isabel Alvarez, M

Iturriaga, Enrique A

Kuo, Alan

Lang, B Franz

Lavin, Jose L

Lee, Soo Chan

Li, Wenjun

Lindquist, Erika

Lopez-Garcia, Sergio

Luque, Eva M

Marcet-Houben, Marina

Marcos, Ana T

Martin, Joel

McCluskey, Kevin

Medina, Humberto R

Miralles-Duran, Alejandro

Miyazaki, Atsushi

Munoz-Torres, Elisa

Oguiza, Jose A

Ohm, Robin A

Olmedo, Maria

Orejas, Margarita

Ortiz-Castellanos, Lucila

Pisabarro, Antonio G

Polaino, Silvia

Rodriguez-Romero, Julio

Ruiz-Herrera, Jose

Ruiz-Vazquez, Rosa

Salamov, Asaf

Sanz, Catalina

Schackwitz, Wendy

Schmutz, Jeremy

Shahriari, Mahdi

Shelest, Ekaterina

Silva-Franco, Fatima

Soanes, Darren

Syed, Khajamohiddin

Tagua, Victor G

Talbot, Nicholas J

Thon, Michael R

Tice, Hope

Torres-Martinez, Santiago

Villalobos-Escobedo, Jose M

Wiebenga, Ad

Yadav, Jagjit S

Current Biology

PubMed

Plants and fungi use light and other signals to regulate development, growth, and metabolism. The fruiting bodies of the fungus Phycomyces blakesleeanus are single cells that react to environmental cues, including light, but the mechanisms are largely unknown [1]. The related fungus Mucor circinelloides is an opportunistic human pathogen that changes its mode of growth upon receipt of signals from the environment to facilitate pathogenesis [2]. Understanding how these organisms respond to environmental cues should provide insights into the mechanisms of sensory perception and signal transduction by a single eukaryotic cell, and their role in&nbsp;pathogenesis. We sequenced the genomes of P.&nbsp;blakesleeanus and M.&nbsp;circinelloides and show that they have been shaped by an extensive genome duplication or, most likely, a whole-genome duplication (WGD), which is rarely observed in fungi [3-6]. We show that the genome duplication has expanded gene families, including those involved in signal transduction, and that duplicated genes have specialized, as evidenced by differences in their regulation by light. The transcriptional response to light varies with the developmental stage and is still observed in a photoreceptor mutant of P. blakesleeanus. A phototropic mutant of P.&nbsp;blakesleeanus with a heterozygous mutation in the photoreceptor gene madA demonstrates that photosensor dosage is important for the magnitude of signal transduction. We conclude that the genome duplication provided the means to improve signal transduction for enhanced perception of environmental signals. Our results will help to understand the role of genome dynamics in the evolution of sensory perception in eukaryotes

Villalobos-Escobedo, José M

Álvarez, M Isabel

Cánovas, David

Cerdá-Olmedo, Enrique

Domínguez, Angel

Eliáš, Marek

Gutiérrez, Gabriel

Lavín, José L

López-García, Sergio

Miralles-Durán, Alejandro

Muñoz-Torres, Elisa

Oguiza, José A

Olmedo, María

Rodríguez-Romero, Julio

Ruiz-Herrera, José

Ruiz-Vázquez, Rosa

Silva-Franco, Fátima

Tagua, Víctor G

Torres-Martínez, Santiago

Gabaldón, Toni

eScholarship - University of California

English

Expansion of Signal Transduction Pathways in Fungi by Extensive Genome Duplication

Plants and fungi use light and other signals to regulate development, growth, and metabolism. The fruiting bodies of the fungus Phycomyces blakesleeanus are single cells that react to environmental cues, including light, but the mechanisms are largely unknown [1]. The related fungus Mucor circinelloides is an opportunistic human pathogen that changes its mode of growth upon receipt of signals from the environment to facilitate pathogenesis [2]. Understanding how these organisms respond to environmental cues should provide insights into the mechanisms of sensory perception and signal transduction by a single eukaryotic cell, and their role in pathogenesis. We sequenced the genomes of P. blakesleeanus and M. circinelloides and show that they have been shaped by an extensive genome duplication or, most likely, a whole-genome duplication (WGD), which is rarely observed in fungi [3–6]. We show that the genome duplication has expanded gene families, including those involved in signal transduction, and that duplicated genes have specialized, as evidenced by differences in their regulation by light. The transcriptional response to light varies with the developmental stage and is still observed in a photoreceptor mutant of P. blakesleeanus. A phototropic mutant of P. blakesleeanus with a heterozygous mutation in the photoreceptor gene madA demonstrates that photosensor dosage is important for the magnitude of signal transduction. We conclude that the genome duplication provided the means to improve signal transduction for enhanced perception of environmental signals. Our results will help to understand the role of genome dynamics in the evolution of sensory perception in eukaryotes

Corrochano, LM

Kuo, A

Marcet-Houben, M

Polaino, S

Salamov, A

Villalobos-Escobedo, JM

Grimwood, J

Álvarez, MI

Avalos, J

Bauer, D

Benito, EP

Benoit, I

Burger, G

Camino, LP

Cánovas, D

Cerdá-Olmedo, E

Cheng, JF

Domínguez, A

Eliáš, M

Eslava, AP

Glaser, F

Gutiérrez, G

Heitman, J

Henrissat, B

Iturriaga, EA

Lang, BF

Lavín, JL

Lee, SC

Li, W

Lindquist, E

López-García, S

Luque, EM

Marcos, AT

Martin, J

McCluskey, K

Medina, HR

Miralles-Durán, A

Miyazaki, A

Muñoz-Torres, E

Oguiza, JA

Ohm, RA

Olmedo, M

Orejas, M

Ortiz-Castellanos, L

Pisabarro, AG

Rodríguez-Romero, J

Ruiz-Herrera, J

Ruiz-Vázquez, R

Sanz, C

Schackwitz, W

Shahriari, M

Shelest, E

Silva-Franco, F

Soanes, D

Syed, K

Tagua, VG

Talbot, NJ

Thon, MR

Tice, H

de Vries, RP

Wiebenga, A

Yadav, JS

Braun, EL

Baker, SE

Garre, V

Schmutz, J

Horwitz, BA

Torres-Martínez, S

Idnurm, A

Herrera-Estrella, A

Gabaldón, T

Grigoriev, IV

University of Liverpool Repository

Luis M. Corrochano

Alan Kuo

Marina Marcet-Houben

Silvia Polaino

Asaf Salamov

José M. Villalobos-Escobedo

Jane Grimwood

M. Isabel Álvarez

Javier Avalos

Diane Bauer

Ernesto P. Benito

Isabelle Benoit

Gertraud Burger

Lola P. Camino

David Cánovas

Enrique Cerdá-Olmedo

Jan-Fang Cheng

Angel Domínguez

Marek Eliáš

Arturo P. Eslava

Fabian Glaser

Gabriel Gutiérrez

Joseph Heitman

Bernard Henrissat

Enrique A. Iturriaga

B. Franz Lang

José L. Lavín

Soo Chan Lee

Wenjun Li

Expansion of Signal Transduction Pathways in Fungi by Extensive Genome Duplication

Abstract

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