Arthur Taylor

Babič

Barrow

Basuki

Bloemen

Bogart

Boyer

Bull

Calatayud

Chen

Chung

Cortajarena

Cromer Berman

Dave J. Adams

Griffiths

Huang

Ittrich

Kehrer

Kettler

Laurent

Lison

Matthew J. Rosseinsky

Michael Barrow

Modo

Molday

Naumova

Neoh

Patricia Murray

Petri-Fink

Pickard

Pino

Pisanic

Reddy

Roshchina

Sakulkhu

Samal

Sarkar

Silva

Singh

Soenen

Taylor

Teeguarden

Tennstaedt

Veiseh

Iron oxide nanoparticles (IONPs, sometimes called superparamagnetic iron oxide nanoparticles or SPIONs) have already shown promising results for in vivo cell tracking using magnetic resonance imaging (MRI). To fully exploit the potential of these materials as contrast agents, there is still a need for a greater understanding of how they react to physiological conditions. A key aspect is the specific nature of the surface coating, which can affect important properties of the IONPs such as colloidal stability, toxicity, magnetism and labelling efficiency. Polymers are widely used as coatings for IONPs as they can increase colloidal stability in hydrophilic conditions, as well as protect the iron oxide core from degradation. In this tutorial review, we will examine the design and synthesis approaches currently being employed to produce polymer coated IONPs as cell tracking agents, and what considerations must be made. We will also give some perspective on the challenges and limitations that remain for polymer coated IONPs as MRI contrast agents for stem cell tracking

Barrow, Michael

Taylor, Arthur

Murray, Patricia

Rosseinsky, Matthew J

Adams, Dave J

University of Liverpool Repository

Design considerations for the synthesis of polymer coated iron oxide nanoparticles for stem cell labelling and tracking using MRI

Barrow, M

Taylor, A

Murray, P

Rosseinsky, MJ

Adams, DJ

This tutorial review provides an introduction to the design, polymer selection and synthesis strategies that can be used to develop biocompatible polymer coatings for iron oxide nanoparticles as MRI contrast agents for stem cell tracking.</p

Crossref

Chemical Society Reviews

Design considerations for the synthesis of polymer coated iron oxide nanoparticles for stem cell labelling and tracking using MRI

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University of Liverpool Repository

University of Liverpool Repository

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