This is an Open Access article distributed under the terms of the Creative Commons Attribution Licens

Alireza Minagar

Lawrence L Horstman

Steven Alex

Wenche Jy

William A Sheremata

Yeon S Ahn

Journal of Neuroinflammation

English

PubMed

J STEVEN Alexander

Springer - Publisher Connector

Evidence of platelet activation in multiple sclerosis

Abstract Objective A fatality in one multiple sclerosis (MS) patient due to acute idiopathic thrombocytopenic purpura (ITP) and a near fatality in another stimulated our interest in platelet function abnormalities in MS. Previously, we presented evidence of platelet activation in a small cohort of treatment-naive MS patients. Methods In this report, 92 normal controls and 33 stable, untreated MS patients were studied. Platelet counts, measures of platelet activation [plasma platelet microparticles (PMP), P-selectin expression (CD62p), circulating platelet microaggragtes (PAg)], as well as platelet-associated IgG/IgM, were carried out. In addition, plasma protein S activity was measured. Results Compared to controls, PMP were significantly elevated in MS (p  Conclusion Platelets are significantly activated in MS patients. The mechanisms underlying this activation and its significance to MS are unknown. Additional study of platelet activation and function in MS patients is warranted.</p

Alexander J Steven

Ahn Yeon S

Horstman Lawrence L

Jy Wenche

Sheremata William A

Minagar Alireza

Directory of Open Access Journals

Sheremata, William A

Jy, Wenche

Horstman, Lawrence L

Ahn, Yeon S

Alexander, J Steven

Minagar, Alireza

University of Miami: Scholarship@Miami

Crossref

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Evidence of platelet activation in multiple sclerosis

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Springer - Publisher Connector

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University of Miami: Scholarship@Miami

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