This is an Open Access article distributed under the terms of the Creative Commons Attribution Licens

Alireza Minagar

Lawrence L Horstman

Steven Alex

Wenche Jy

William A Sheremata

Yeon S Ahn

Journal of Neuroinflammation

English

PubMed

Springer - Publisher Connector

Evidence of platelet activation in multiple sclerosis

J STEVEN Alexander

Abstract Objective A fatality in one multiple sclerosis (MS) patient due to acute idiopathic thrombocytopenic purpura (ITP) and a near fatality in another stimulated our interest in platelet function abnormalities in MS. Previously, we presented evidence of platelet activation in a small cohort of treatment-naive MS patients. Methods In this report, 92 normal controls and 33 stable, untreated MS patients were studied. Platelet counts, measures of platelet activation [plasma platelet microparticles (PMP), P-selectin expression (CD62p), circulating platelet microaggragtes (PAg)], as well as platelet-associated IgG/IgM, were carried out. In addition, plasma protein S activity was measured. Results Compared to controls, PMP were significantly elevated in MS (p  Conclusion Platelets are significantly activated in MS patients. The mechanisms underlying this activation and its significance to MS are unknown. Additional study of platelet activation and function in MS patients is warranted.</p

Alexander J Steven

Ahn Yeon S

Horstman Lawrence L

Jy Wenche

Sheremata William A

Minagar Alireza

Directory of Open Access Journals

Sheremata, William A

Jy, Wenche

Horstman, Lawrence L

Ahn, Yeon S

Alexander, J Steven

Minagar, Alireza

University of Miami: Scholarship Miami

Crossref

Ahn YS: Association of immune thrombocytopenia and abnormal platelet functions with multiple sclerosis (Abstract). Brain Pathol

Ahn YS: Cell-derived microparticles and exosomes in neuroinflammatory conditions [Review]. Int Rev Neurobiol

Ahn YS: Clinical significance of platelet microparticles in autoimmune thrombocytopenias.

Ahn YS: Desmopressin [DDAVP] acts on platelets to generate platelet microparticles and enhanced procoagulant activity. Thromb Res

Ahn YS: Elevated plasma endothelial microparticles in multiple sclerosis. Neurology

Ahn YS: Elevated platelet microparticles in transient ischemic attacks, lacunar infarcts, and multiinfarct dementias. Thromb Res

AM: Assessment of platelet activation in several different anticoagulants by the Advia 120 Hematology System, fluorescence flow cytometry, and electron microscopy. Thromb Haemost

CA: The evolving role of platelets in inflammation.

CR: T-cell function and migration: Two sides of the same coin.

Elevated endothelial microparticles in thrombotic thrombocytopenic purpura (TTP): Findings from brain and renal microvascular cell culture and patients with active disease.

Gil-Peralta A: Relacion entree sclerosis multiple, enfermedad de Hodgkin y purpura trombocitopenica idiopatica. Relations among multiple sclerosis, Hodgkin's disease and idiopathic thrombocytopenic purpura. Neurologia

Hughes GR: Can neurological manifestations of Hughes (antiphospholipid) syndrome be distinguished from multiple sclerosis? Analysis of 27 patients and review of the literature. Medicine (Baltimore)

Idiopathic thrombocytopenic purpura in patients with multiple sclerosis. (Abstract). Multiple Sclerosis

JH: Comparison of anticoagulant and procoagulant activities of stimulated platelets and platelet-derived microparticles. Blood

L: Proteomic analysis of active multiple sclerosis lesions reveals therapeutic targets. Nature

Losche W: Transfer of tissue factor from platelets to monocytes: role of plateletderived microvesicles and CD62P. Thromb Haemost

Minagar A: Clinical and neuroimaging correlates of antiphospholipid antibodies in multiple sclerosis: a preliminary study.

Myerberg RJ: Chronic platelet activation and acute coronary syndromes in 13 middle-aged patients. Clin Appl Thromb Hemost

MZ: Platelet- and megakaryocyte-derived microparticles transfer CXCR4 receptor to CXCR4-null cells and make them susceptible to infection by X4-HIV. AIDS

Platelet microparticles, a transcellular delivery system for RANTES promoting monocyte recruitment on endothelium. Arterioscl Thromb Vasc Biol

Platelet-derived microparticles induce angiogenesis and stimulate postischemic revascularization. Cardiovasc Res

Powe NR: Prevalence of immune thrombocytopenia: analyses of administrative data.

Prevalence of other autoimmune diseases in patients with multiple sclerosis. Multiple Sclerosis 2005, 11(Suppl 1):S29.

Ratajczak MZ: Membrane-derived microvesicles: Important and under-appreciated mediators of cel-to-cell communication. Leukemia

Ratajczak MZ: Microvesicles derived from activated platelets induce metastasis and angiogenesis in lung cancer.

RC: Activated platelet aggregates in thrombotic thrombocytopenic purpura: decrease with plasma infusions and normalization in remission.

Savistsky JP: Platelet adhesive index studies in multiple sclerosis and other neurologic disorders.

SN: Platelet microparticles induce angiogenesis in vitro.

Studies in multiple sclerosis (iv) 'encephalitis' and sclerotic plaques produced by venular obstruction. Arch Neurol Neurosurg Psychiat

Surprenant A: Rapid secretion of interleukin-1β by microvesicle shedding. Immunity

T: The role of alpha-4 Integrin in the aetiology of multiple sclerosis: current knowledge and therapeutic implications. CNS Drugs

The association between tissue factor-exposing microparticles and the activation of the coagulation system in cancer patients. Blood

The presence and release of tissue factor from human platelets. Platelets

The role of human platelet membrane receptors in inflammation [Ch 4].

Thlarmin F: Association sclerose en plaques et thrombopenie auto-immune. Rev Med Interne

WJ: Longterm danazol therapy in ITP: unmaintained remissions and age dependent response in women. Ann Int Med

Yamamoto Y: Characterization of serum anti-phospholipid antibodies in patients with multiple sclerosis.

YS: A flow cytometric assay of platelet activation marker P-selectin (CD62p) distinguishes heparin-induced thrombocytopenia (HIT) from HIT-with-thrombosis (HITT). Thromb Haemost

YS: Complement mediated fragmentation and lysis of opsonized platelets: Gender differences in sensitivity.

YS: Cutaneous reactions to recombinant human interferon beta-1b: the clinical and histologic spectrum.

YS: Platelet aggregates as markers of platelet activation: Characterization of flow cytometric method suitable for clinical applications.

YS: Platelet factor 3 in plasma fractions: Its relation to microparticle size and thromboses. Thromb Res

YS: Platelet microparticles bind, activate and aggregate neutrophils in vitro. Blood Cells Mol Dis

Zilkha KJ: Platelet adhesiveness in multiple sclerosis. Lancet

http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.275.2177

Evidence of platelet activation in multiple sclerosis

Abstract

Similar works

Full text

Available Versions

Springer - Publisher Connector

Springer - Publisher Connector

Directory of Open Access Journals

University of Miami: Scholarship Miami

Crossref