Congenital absence of the gall-bladder is a rare condition. It is sometimes associated with other
congenital defects. We report here two cases of gall-bladder agenesis discovered at laparoscopy.
Both had a history of skeletal and cardiovascular anomalies. The investigation of patients with
absent gall-bladder can be very difficult. Ultrasound scanning is usually inconclusive and
further noninvasive tests should be performed to establish the diagnosis and prevent an
unnecessary operation. The presence of other congenital defects should alert the clinician to the
possibility of gall-bladder agenesis