ASF Lok

B Fisher

B Ma

B Zee

CA Liao

G Rossi

GC Wong

GK Lau

GL Bird

JA Hanley

JH Hoofnagle

JL Steinberg

K C Lam

K Kumagai

LL Lim

LT Soh

M Omata

M Persico

O Shibolet

P J Johnson

P K S Chan

PC Pinto

RHS Liang

RM Galbraith

S Markovic

S Zhong

SN Thung

SW Chan

T Ehata

TL Liang

VYN Lau

W M Ho

W Yeo

W-L Wong

Y Nokamura

YF Liaw

English

PubMed

Crossref

Comprehensive analysis of risk factors associating with Hepatitis B virus (HBV) reactivation in cancer patients undergoing cytotoxic chemotherapy

For cancer patients with chronic hepatitis B virus (HBV) infection, who receive cytotoxic chemotherapy, HBV reactivation is a well-described complication, which may result in varying degrees of liver damage. Several clinical features and the pre-chemotherapy HBV viral load have been suggested to be associated with an increased risk of developing the condition: (1). to assess the clinical and virological factors in a comprehensive manner and thereby identify those that are associated with the development of HBV reactivation; (2). to develop a predictive model to quantify the risk of HBV reactivation. In all, 138 consecutive cancer patients who were HBV carriers and undergoing chemotherapy were studied, of which 128 patients had sera available for real-time PCR HBV DNA measurement. They were followed up throughout their course of chemotherapy and the HBV reactivation rate was determined. The clinical and virological features between those who did and did not develop viral reactivation were compared. These included age, sex, baseline liver function tests, HBeAg status and viral load (HBV DNA) prior to the chemotherapy, and the use of specific cytotoxic agents. In all, 36 (26%) developed HBV reactivation. Multivariate analysis revealed pre-chemotherapy HBV DNA level, the use of steroids and a diagnosis of lymphoma or breast cancer to be significant factors. Based on real-time HBV DNA PCR assay, detectable baseline HBV DNA prior to the administration of cytotoxic chemotherapy, the use of steroids and a diagnosis of lymphoma or breast cancer are predictive factors for the development of HBV reactivation. A predictive model was developed from the current data, based on a logistic regression method

Yeo, W

Zee, B

Zhong, S

Chan, PK

Wong, WL

Ho, WM

Lam, KC

Johnson, Philip

Pang, E

Yim, A

University of Birmingham Research Portal

Comprehensive analysis of risk factors associating with hepatitis B virus (HBV) reactivation in cancer patients undergoing cytotoxic chemotherapy

Acute liver decompensation on withdrawal of cytotoxic and immunosuppressive therapy in hepatitis B carriers.

http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2409681

Comprehensive analysis of risk factors associating with Hepatitis B virus (HBV) reactivation in cancer patients undergoing cytotoxic chemotherapy

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University of Birmingham Research Portal

University of Birmingham Research Portal