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A Ariyasinghe

AA Lamikanra

ALL Neill

AM Prentice

B Genton

B Meister

Catherine Bourgouin

Catherine Thouvenot

CP Liang

Delphine Depoix

F Lonnqvist

G Matarese

GM Lord

H Lan

HC van der Heyde

J Lou

JB De Souza

JL Deen

K Elased

KM Elased

M Moumaris

M Pulido-Mendez

M Tanner

Marie-Noëlle Lombard

MC Mbago

ME Onwuamaegbu

MN Lombard

N Takahashi

NF Delahaye

O Shalev

P Amuna

P Sinnis

Philippe Grellier

PU Dubuc

RA Memon

RG Hendrickse

RM Tarsi

T Gainsford

UE Schaible

Vincent Robert

English

PubMed

International audienceBackground: The relationship between malaria and obesity are largely unknown. This is partly due to the fact that malaria occurs mainly in tropical areas where, until recently, obesity was not prevalent. It now appears, however, that obesity is emerging as a problem in developing countries. To investigate the possible role of obesity on the host-parasite response to malarial infection, this study applied a murine model, which uses the existence of genetically well characterized obese mice.Methods: The receptivity of obese homozygous ob/ob mice was compared to the receptivity of control heterozygous ob/+ lean mice after a single injection of Plasmodium berghei ANKA sporozoites. Both parasitaemia and mortality in response to infection were recorded.Results: The control mice developed the expected rapid neurological syndromes associated with the ANKA strain, leading to death after six days, in absence of high parasitaemia. The obese mice, on the other hand, did not develop cerebral malaria and responded with increasing parasitaemia, which produced severe anemia leading to death 18–25 days after injection.Conclusion:The observed major differences in outward symptoms for malarial infection in obese versus control mice indicate a link between obesity and resistance to the infection which could be addressed by malariologists studying human malaria

Robert, Vincent

Bourgouin, Catherine

Depoix, Delphine

Thouvenot, C

Lombard, M-N

Grellier, Philippe

HAL: Hyper Article en Ligne

Malaria and obesity : obese mice are resistant to cerebral malaria

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Malaria and obesity: obese mice are resistant to cerebral malaria

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Bourgouin, C.

Depoix, D.

Thouvenot, C.

Lombard, M. N.

Grellier, P.

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Malaria and obesity: obese mice are resistant to cerebral malaria

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HAL: Hyper Article en Ligne

Archive Ouverte en Sciences de l'Information et de la Communication

Crossref

HAL-Pasteur

Springer - Publisher Connector

Springer - Publisher Connector

HAL-IRD

Horizon / Pleins textes