CD1a-positive infiltrating-dendritic cell density and 5-year survival from human breast cancer

A Eisenthal; A Troy; AJ Nixon; AJ Troy; AJ Troy; B J Coventry; BJ Coventry; BJ Coventry; BJ Coventry; BJ Coventry; BJ Coventry; BJ Coventry; C Willgeroth; CA Makin; CN Baxevanis; CW Elston; CW Heizmann; D Bell; D Vitolo; D Vitolo; DI Gabrilovich; DJ Schwartzentruber; DL Page; EE Hillenbrand; F Basset; G Bigotti; H Matsuda; H Nomori; H Pereira; HJG Bloom; J Morton; JA Austyn; K Ambe; K Inoue; K Kikuchi; KC Gatter; L Lespagnard; LW Dalton; M Iwamoto; MH Galea; MS Dunnill; MS Younes; NA Zeid; O Gallo; O Gallo; P Schenk; PA Sieling; PB Bethwaite; R David; RM Dallal; RW Scarff; S Hammar; S Schroder; S Tsujitani; S Veronesi; SA Goldman; SB Fox; SE Pinder; T Furukawa; T Tsuge; TL Whiteside; TL Whiteside; Z Zeng

CD1a-positive infiltrating-dendritic cell density and 5-year survival from human breast cancer

Abstract

© Churchill LivingstoneInfiltrating CD1a+ dendritic cells (DCs) have been associated with increased survival in a number of human cancers. This study investigated DC infiltration within breast cancers and the association with survival. Classical established prognostic factors, of tumour size, lymph node status, histological grade, lympho-vascular invasion, the KI-67 (MIB-1) fraction and the Nottingham Prognostic Index (NPI) were also compared. A total of 48 breast cancer patients were followed from the time of surgery and CD1a density analysis for 5 years or until death. Our data set validated previous studies, which show a relationship between survival and the NPI (P<0.001), tumour size (P<0.01) and lymph node status (P<0.05). Although more patients were alive at the 5-year time point in the group with higher CD1a DC density than the lower CD1a DC group, this failed to reach statistical significance at the P=0.05 level. Analysis at 10 years postsurgery is required to investigate the association further.B.J.Coventry and J. Morto