Article on heart rate variability characteristics in sedentary postmenopausal women following six months of exercise training

A Algra

A Britton

AJ Schuit

AR Yataco

B Ekblom

Carl J. Lavie

CL Brockbank

Conrad P. Earnest

D Lucini

ED Eaker

EM Dixon

GM Morss

H Ito

H Tsuji

HH Dickhuth

HV Huikuri

JB Schwartz

JM Evans

Jose AL Calbet

K Shin

KP Davy

KR Westerterp

L Fluckiger

L Mosca

ME Nelson

MR Carnethon

MT La Rovere

O Bertel

PG Katona

PP Jones

PR Myslivecek

R Furlan

R Jurca

R Perini

S Reland

SF Lewis

SN Blair

SS Hull Jr

Steven N. Blair

TB Kuo

Timothy S. Church

TS Church

WC Levy

WL Haskell

Y Arai

PLoS ONE

English

PubMed

Crossref

Heart Rate Variability Characteristics in Sedentary Postmenopausal Women Following Six Months of Exercise Training: The DREW Study

Decreased heart rate variability (HRV) is associated with a higher risk of mortality. Overall, postmenopausal women have lower levels of HRV than premenopausal women, which may be additionally complicated by lifestyle related behaviors such as physical inactivity and obesity. Though cardiorespiratory exercise training increases HRV, little is known regarding the exercise dose necessary to promote this improvement.Our primary aim was to measure HRV in post-menopausal women following 6-months of exercise training. We examined supine resting HRV in 373 post-menopausal women (45-75 y) after 6-months of randomly assigned and double-blinded administered exercise training exercise training at 50%, 100% and 150% of the NIH Consensus Development Panel's recommended minimal physical activity level. This corresponded to 4, 8, or 12 kcal/kg per week (KKW) of energy expenditure. At baseline, we observed no significant differences in HRV or hormone replacement use between treatment groups. However, we did observe that Caucasian women and those taking antidepressant medications had lower levels of baseline HRV. After 6-months of exercise intervention, we observed a dose dependent increase in all parasympathetically derived time and frequency domain measurements across exercise groups after adjustment for age, ethnicity, antidepressants, and baseline rMSSD (all, P<0.001). For example, the parasympathetic index rMSSD was greater than control (23.19+/-1.0) for the 4-KKW (25.98+/-0.8; P = 0.14), 8-KKW (27.66+/-1.0; P<0.05), and 12-KKW (27.40+/-0.0; P<0.05) groups at follow-up.Moderate intensity exercise training exercise is sufficient to improve HRV in previously sedentary postmenopausal women in a dose-dependent manner, as 4-KKW is insufficient to improve parasympathetic indices of HRV, while 12-KKW conferred no greater improvement than 8-KKW.Clinicaltrials.gov NCT 00011193

Conrad P Earnest

Carl J Lavie

Steven N Blair

Timothy S Church

Directory of Open Access Journals

Heart rate variability characteristics in sedentary postmenopausal women following six months of exercise training: the DREW study.

Decreased heart rate variability (HRV) is associated with a higher risk of mortality. Overall, postmenopausal women have lower levels of HRV than premenopausal women, which may be additionally complicated by lifestyle related behaviors such as physical inactivity and obesity. Though cardiorespiratory exercise training increases HRV, little is known regarding the exercise dose necessary to promote this improvement.Our primary aim was to measure HRV in post-menopausal women following 6-months of exercise training. We examined supine resting HRV in 373 post-menopausal women (45–75 y) after 6-months of randomly assigned and double-blinded administered exercise training exercise training at 50%, 100% and 150% of the NIH Consensus Development Panel's recommended minimal physical activity level. This corresponded to 4, 8, or 12 kcal/kg per week (KKW) of energy expenditure. At baseline, we observed no significant differences in HRV or hormone replacement use between treatment groups. However, we did observe that Caucasian women and those taking antidepressant medications had lower levels of baseline HRV. After 6-months of exercise intervention, we observed a dose dependent increase in all parasympathetically derived time and frequency domain measurements across exercise groups after adjustment for age, ethnicity, antidepressants, and baseline rMSSD (all, P<0.001). For example, the parasympathetic index rMSSD was greater than control (23.19±1.0) for the 4-KKW (25.98±0.8; P = 0.14), 8-KKW (27.66±1.0; P<0.05), and 12-KKW (27.40±0.0; P<0.05) groups at follow-up.Moderate intensity exercise training exercise is sufficient to improve HRV in previously sedentary postmenopausal women in a dose-dependent manner, as 4-KKW is insufficient to improve parasympathetic indices of HRV, while 12-KKW conferred no greater improvement than 8-KKW

Earnest Conrad P.

Lavie Carl J.

Blair Steven N.

Church Timothy S.

Public Library of Science (PLOS)

Earnest, Conrad P.

Lavie, Carl J.

Blair, Steven N.

Church, Timothy S.

UNT (University of North Texas) Digital Library

Background: Decreased heart rate variability (HRV) is associated with a higher risk of mortality. Overall, postmenopausal women have lower levels of HRV than premenopausal women, which may be additionally complicated by lifestyle related behaviors such as physical inactivity and obesity. Though cardiorespiratory exercise training increases HRV, little is known regarding the exercise dose necessary to promote improvement.
Methodology/Principle Findings: Our primary aim was to measure HRV in post-menopausal women following 6-moths of exercise training. We examined supine resting HRV in 373 post-menopausal women (45-75 y) after 6-months of randomly assigned and double-blinded administered exercise training exercise training at 50%, 100% and 150% of the NIH Consensus Development Panel\u27s recommended minimal physical activity level. This corresponded to 4, 8, or 12 kcal/kg per week (KKW) of energy expenditure. At baseline, we observed no significant differences in HRV or hormone replacement use between treatment groups. However, we did observe that Caucasian women and those taking antidepressant medications had lower levels of baseline HRV. After 6-months of exercise intervention, we observed a dose dependent increase in all parasympathetically derived time and frequency domain measurements across exercise groups after adjustment for age, ethnicity, antidepressants, and baseline rMSSD (all, P\u3c0.001). For example, the parasympathetic index rMSSD was greater than control (23.19±1.0) for the 4-KKW (25.98±0.8; P=0.14), 8-KKW (27.66±1.0; P\u3c0.05), and 12-KKW (27.40±0.0; P\u3c0.05) groups at follow-up.
Conclusions/Significance: Moderate intensity exercise training exercise is sufficient to improve HRV in previously sedentary postmenopausal women in a dose-dependent manner, as 4-KKW is insufficient to improve parasympathetic indices of HRV, while 12-KKW conferred no greater improvement than 8-KKW

Scholar Commons - Institutional Repository of the University of South Carolina

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Heart Rate Variability Characteristics in Sedentary Postmenopausal Women Following Six Months of Exercise Training: The DREW Study

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Directory of Open Access Journals

Public Library of Science (PLOS)

Public Library of Science (PLOS)

UNT (University of North Texas) Digital Library

Scholar Commons - Institutional Repository of the University of South Carolina