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Identification of human renal cell carcinoma associated genes by suppression subtractive hybridization
Authors
Avantagiatti ML
Bartkova J
+81Β more
Bennett BD
Brambilla E
Bremers AJ
Brown JM
Bukowski RM
Christensen CR
Conover CA
Conrad PW
De Plaen E
Freeman MR
Gerwins P
Harris SR
Hedberg Y
Hendrix MJ
Hoffman DM
Hofmockel G
Huang YW
Ishikawa J
Jares P
Kanapuli SP
Kaplan CD
Kawagoe H
Kerbel RS
Khan J
Kim I
Kirschmann DA
Kuang WW
Kunkel LM
Kurzrock R
Lager DJ
Lamar EE
Lee HY
Lee YH
Li YM
Liang P
Lin BT
Mark MD
Martin-Satue M
Meng JY
Mickisch GH
Moch H
Moch H
Motzer RJ
Nieder C
Obata S
Oshika Y
Paul R
Pawelec G
Pitzer C
Raju KS
Ravaud A
Reis M
Rosen L
Sahin U
Sargent ER
Shimazui T
Shimoyama Y
Somers KD
Stasser M
Stracke ML
Stracke ML
Thompson EW
Tian H
Tomisawa M
Tran J
Ullrich A
Vassar R
Vaupel PW
Wang RF
Weidner N
Weinberg RA
Weiss H
Wen Y
Wiesener MS
Williamson JR
Xin H
Yamaguchi Y
Yang Y
Yoshida K
Yu AE
Zhang SY
Publication date
Publisher
Nature Publishing Group
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PubMed
Abstract
Renal cell carcinoma (RCC) are frequently chemo- and radiation resistant. Thus, there is a need for identifying biological features of these cells that could serve as alternative therapeutic targets. We performed suppression subtractive hybridization (SSH) on patient-matched normal renal and RCC tissue to identify variably regulated genes. 11 genes were strongly up-regulated or selectively expressed in more than one RCC tissue or cell line. Screening of filters containing cancer-related cDNAs confirmed overexpression of 3 of these genes and 3 additional genes were identified. These 14 differentially expressed genes, only 6 of which have previously been associated with RCC, are related to tumour growth/survival (EGFR, cyclin D1, insulin-like growth factor-binding protein-1 and a MLRQ sub-unit homologue of the NADH:ubiquinone oxidoreductase complex), angiogenesis (vascular endothelial growth factor, endothelial PAS domain protein-1, ceruloplasmin, angiopoietin-related protein 2) and cell adhesion/motility (protocadherin 2, cadherin 6, autotaxin, vimentin, lysyl oxidase and semaphorin G). Since some of these genes were overexpressed in 80β90% of RCC tissues, it is important to evaluate their suitability as therapeutic targets. Β© 2001 Cancer Research Campaig
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Last time updated on 03/12/2019