CORE
🇺🇦
make metadata, not war
Services
Services overview
Explore all CORE services
Access to raw data
API
Dataset
FastSync
Content discovery
Recommender
Discovery
OAI identifiers
OAI Resolver
Managing content
Dashboard
Bespoke contracts
Consultancy services
Support us
Support us
Membership
Sponsorship
Community governance
Advisory Board
Board of supporters
Research network
About
About us
Our mission
Team
Blog
FAQs
Contact us
Analysis of the TGFβ functional pathway in epithelial ovarian carcinoma
Authors
Cardillo MR
Cardillo MR
+32 more
Cardillo MR
Chen R-H
Chenevix-Trench G
Chenevix-Trench G
Cooke I
De Souza AT
De Souza AT
Garrigue-Antar L
Gerdes MJ
Goff BA
Guo Y
Haber DA
Hollstein M
Jirtle RL
Landis S
Lynch MA
Makar AP
Munger JS
Obata K
Orita M
Polyak K
Rich JN
Tammella J
Taylor S
ten Dijke P
Tsukazaki T
Vincent F
Wang D
Wang D
Wright K
Yan Z
Zhang F
Publication date
1 January 2001
Publisher
Nature Publishing Group
Doi
Cite
View
on
PubMed
Abstract
Epithelial ovarian carcinoma is often diagnosed at an advanced stage of disease and is the leading cause of death from gynaecological neoplasia. The genetic changes that occur during the development of this carcinoma are poorly understood. It has been proposed that IGFIIR, TGFβ1 and TGFβRII act as a functional unit in the TGFβ growth inhibitory pathway, and that somatic loss-of-function mutations in any one of these genes could lead to disruption of the pathway and subsequent loss of cell cycle control. We have examined these 3 genes in 25 epithelial ovarian carcinomas using single-stranded conformational polymorphism analysis and DNA sequence analysis. A total of 3 somatic missense mutations were found in the TGFβRII gene, but none in IGFRII or TGFβ1. An association was found between TGFβRII mutations and histology, with 2 out of 3 clear cell carcinomas having TGFβRII mutations. This data supports other evidence from mutational analysis of the PTEN and β-catenin genes that there are distinct developmental pathways responsible for the progression of different epithelial ovarian cancer histologic subtypes. © 2001 Cancer Research Campaign http://www.bjcancer.co
Similar works
Full text
Open in the Core reader
Download PDF
Available Versions
University of Melbourne Institutional Repository
See this paper in CORE
Go to the repository landing page
Download from data provider
oai:jupiter.its.unimelb.edu.au...
Last time updated on 29/04/2021
University of Queensland eSpace
See this paper in CORE
Go to the repository landing page
Download from data provider
oai:espace.library.uq.edu.au:U...
Last time updated on 30/08/2013
Crossref
See this paper in CORE
Go to the repository landing page
Download from data provider
Last time updated on 11/12/2019