CORE
🇺🇦
make metadata, not war
Services
Services overview
Explore all CORE services
Access to raw data
API
Dataset
FastSync
Content discovery
Recommender
Discovery
OAI identifiers
OAI Resolver
Managing content
Dashboard
Bespoke contracts
Consultancy services
Support us
Support us
Membership
Sponsorship
Community governance
Advisory Board
Board of supporters
Research network
About
About us
Our mission
Team
Blog
FAQs
Contact us
p73 is over-expressed in vulval cancer principally as the Δ2 isoform
Authors
A Bell
L A Brooks
+12 more
T Crook
B Dunne
A Evans
D Evans
P J Farrell
M Gasco
B Gusterson
J O'Nions
A Reddy
M Rozycka
A Sullivan
J A Tidy
Publication date
1 January 2001
Publisher
Nature Publishing Group
Doi
Cite
View
on
PubMed
Abstract
p73 was studied in squamous cancers and precursor lesions of the vulva. Over-expression of p73 occurred commonly in both human papillomavirus (HPV)-positive and -negative squamous cell cancers (SCC) and high-grade premalignant lesions. Whereas expression in normal vulval epithelium was detected only in the basal and supra-basal layers, expression in neoplastic epithelium increased with grade of neoplasia, being maximal at both protein and RNA levels in SCC. p73 Δ2 was the principal over-expressed isoform in the majority of cases of vulval SCC and often the sole form expressed in SCC. Over-expression of p73 was associated with expression of HPV-encoded E7 or with hypermethylation or mutation of p16INK4a in HPV-negative cases. There was a close correlation between expression of p73 and p14ARF in cancers with loss of p53 function. The frequent over-expression of p73 Δ2 in neoplastic but not normal vulval epithelium, and its co-ordinate deregulation with other E2F-1 responsive genes suggests a role in the oncogenic process. © 2001 Cancer Research Campaign http://www.bjcancer.co
Similar works
Full text
Open in the Core reader
Download PDF
Available Versions
Enlighten: Publications
See this paper in CORE
Go to the repository landing page
Download from data provider
oai:eprints.gla.ac.uk:20805
Last time updated on 09/04/2020
Enlighten
See this paper in CORE
Go to the repository landing page
Download from data provider
oai:eprints.gla.ac.uk:20805
Last time updated on 08/10/2012