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Monoclonal antibody ONS-M21 recognizes integrin α3 in gliomas and medulloblastomas
Authors
AE Evans
B Honore
+37 more
C Daumas-Duport
E Mabuchi
E Tominaga
F Daghighian
H Kishima
H Okada
H Suzuki
J Matsuzaki
J Zhao
JA Williams
JB Weitzman
JB Weitzman
K Jaskiewicz
K Shimizu
K Shimizu
K Tamura
K Tamura
M Schrappe
MD Dan
MD Dan
MJ Elices
N Boku
P Kleihues
P Romeijin
P Shiramarao
PL McGeer
S Moriuchi
SC Schold
SG Dastidar
T Faillot
T Hayakawa
T Ohtomo
T Tsuji
W Paulus
Y Fradet
Y Miyao
Y Takada
Publication date
Publisher
Nature Publishing Group
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PubMed
Abstract
The monoclonal antibody ONS-M21 recognizes an antigen found on the surface of glioma and medulloblastoma cells but does not react with the antigens of normal brain tissue. We purified and identified the 140-kDa protein by means of an antibody-binding affinity column. This 140-kDa antigen has sequences homologous to the amino-terminal region and five parts of the internal domain of integrin α3. When the integrin α3-related sequences was amplified and used to analyse the mRNA of glioma and medulloblastoma surgical specimens, the transcription level of integrin α3 mRNA appeared to be quantitatively correlated with the grade of malignancy. These findings suggest that the ONS-M21 antibody, which reacts with integrin α3, might be useful in the diagnosis of gliomas and medulloblastomas. © 1999 Cancer Research Campaig
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Last time updated on 03/01/2020