Abstract Background Malignant esophageal stenosis with complete obstruction and esophagorespiratory fistula (ERF) is difficult to treat with standard endoscopic techniques. Case presentation We report a patient in whom with local recurrence of esophageal carcinoma an esophagotracheal fistula occurred. Initially the patient had undergone esophageal resection with interposition of a gastric tube. Due to complete obstruction of the lumen by recurrent tumor conventional transoral stent placement failed. For retrograde dilatation a laparotomy was performed. Via a duodenal incision endoscopic access to the gastric tube was achieved. Using a guidewire the esophageal obstruction was traversed and dilated. Then it was possible to place an esophageal stent via an antegrade approach. Conclusion Open surgery enables a safe access for retrograde endoscopic therapy in patients who had undergone esophageal resection with gastric interposition.</p

Cupisti, Kenko

Iskender, Özcan

Knoefel, Wolfram T

Kröpil, Patrick

Rehders, Alexander

Renter, Marc A

Schmitt, Marcus

English

PubMed

Alexander Rehders

Kenko Cupisti

Marcus Schmitt

Marc A Renter

Patrick Kröpil

Özcan Iskender

Wolfram T Knoefel

Springer - Publisher Connector

Laparotomy enables retrograde dilatation and stent placement for malignant esophago-respiratory fistula

BioMed Central
World Journal of Surgical Oncology
ssOpen AcceCase report
Laparotomy enables retrograde dilatation and stent placement for 
malignant esophago-respiratory fistula
Alexander Rehders1, Kenko Cupisti*1, Marcus Schmitt2, Marc A Renter1, 
Patrick Kröpil3, Özcan Iskender1 and Wolfram T Knoefel1
Address: 1Klinik für Allgemein-, Viszeral- und Kinderchirurgie, Heinrich Heine Universität, Düsseldorf, Germany, 2Klinik für Gastroenterologie, 
Hepatologie und Infektiologie, Heinrich Heine Universität, Düsseldorf, Germany and 3Institut für diagnostische Radiologie, Heinrich Heine 
Universität, Düsseldorf, Germany
Email: Alexander Rehders - rehders@med.uni-duesseldorf.de; Kenko Cupisti* - cupisti@uni-duesseldorf.de; 
Marcus Schmitt - marcus.schmitt@uni-duesseldorf.de; Marc A Renter - renter@uni-duesseldorf.de; Patrick Kröpil - kroepil@uni-duesseldorf.de; 
Özcan Iskender - iskender@uni-duesseldorf.de; Wolfram T Knoefel - knoefel@uni-duesseldorf.de
* Corresponding author    
Abstract
Background: Malignant esophageal stenosis with complete obstruction and esophagorespiratory
fistula (ERF) is difficult to treat with standard endoscopic techniques.
Case presentation: We report a patient in whom with local recurrence of esophageal carcinoma
an esophagotracheal fistula occurred. Initially the patient had undergone esophageal resection with
interposition of a gastric tube. Due to complete obstruction of the lumen by recurrent tumor
conventional transoral stent placement failed. For retrograde dilatation a laparotomy was
performed. Via a duodenal incision endoscopic access to the gastric tube was achieved. Using a
guidewire the esophageal obstruction was traversed and dilated. Then it was possible to place an
esophageal stent via an antegrade approach.
Conclusion: Open surgery enables a safe access for retrograde endoscopic therapy in patients
who had undergone esophageal resection with gastric interposition.
Background
Esophageal cancer is an aggressive tumor with unfavora-
ble prognosis. Despite the radical surgery, local recurrence
occurs in up to 21% of the cases [1]. Dysphagias as well as
esophago-respiratory fistulae (ERF) are predominant
symptoms of local tumor recurrence and represent devas-
tating and life threatening complications. Patients are
often unable to swallow food or even their own saliva
without aspiration. Unless sufficient palliation is insti-
tuted rapidly, the usual cause of death is pulmonary sepsis
resulting from chronic aspiration. Since covered and self
expandable stents have been introduced, successful palli-
ation has been reported in most patients[2,3]. The endo-
scopic management of malignant obstruction and ERF is
technically challenging and requires careful endoscopic
dilatation with wire guided dilators. Despite of sophisti-
cated endoscopic strategies in some patients the passage
of a guide wire is technically impossible due to a com-
pletely obstructed lumen. In this situation retrograde
endoscopic dilatation via a radio guided percutaneous
gastrostomy is a second option[4].
However in patients who underwent esophageal resection
and transformation of the stomach into a small gastric
Published: 26 January 2008
World Journal of Surgical Oncology 2008, 6:8 doi:10.1186/1477-7819-6-8
Received: 9 July 2007
Accepted: 26 January 2008
This article is available from: http://www.wjso.com/content/6/1/8
© 2008 Rehders et al; licensee BioMed Central Ltd. 
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), 
which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.Page 1 of 4
(page number not for citation purposes)
World Journal of Surgical Oncology 2008, 6:8 http://www.wjso.com/content/6/1/8tube for esophageal reconstruction, retrograde access is far
more challenging, since not even radio guided procedures
seem applicable. To our knowledge a suitable therapeutic
approach in this difficult palliative situation has not been
described before. We recently encountered a patient with
local recurrence after esophageal resection and interposi-
tion of a gastric tube. Due to complete obstruction and
ERF, he required a laparotomy for retrograde passage and
subsequent stent placement.
Case presentation
A 66-year-old man presented with severe dysphagia,
weight loss and recurrent pulmonary infections due to an
esophago-tracheal fistula. Due to squamous cell carci-
noma of the esophagus 17 month ago, he had undergone
esophageal resection and interposition of a gastric tube
with cervical anastomosis. This treatment was followed by
adjuvant radio-chemotherapy (50 Gy with 5-FU and Cis-
platin). The first signs of dysphagia developed 8 weeks
before admission to our hospital. Initial endoscopic ther-
apy revealed local tumor recurrence beginning at 21 cm
from front incisors, but failed to provide palliation of dys-
phagia. The distal end of the stenosis could not be meas-
ured precisely due to high grade stenosis which could not
be passed endoscopically. Though intravenous hyperali-
mentation was administered, the patient kept on losing
weight. Furthermore recurrent pulmonary infections
occurred and swallowing of salvia, without coughing
became impossible. For palliative surgical treatment the
patient was transferred to our institution. Unfortunately
we found the esophageal lumen to be completely
obstructed by recurrent tumor. Moreover the tumor had
invaded the trachea and had caused an esophago-tracheal
fistula. The fistula itself could not be seen endoscopically,
but was found by gastrographin swallow and CT-scan
(Figure 1, Figure 2). According to CT-scan we estimated it
to be located at about 2–3 cm distal from the beginning of
the stenosis. The recurrent mediastinal tumor was esti-
mated to have a length of 6 cm and infiltrated the gastric
tube.
All endoscopic attempts to pass the obstruction failed,
because the guide wire only entered the associated
esophago-tracheal fistula. Therefore a retrograde endo-
scopic approach was undertaken. According to the previ-
ous esophageal resection with interposition of a gastric
tube, radiologically guided percutaneous gastrostomy
techniques [5] had to be rejected. Retrograde access to the
esophageal lumen was obtained by open surgery and a
duodenotomy (Figure 3). Through an endoscope a guide
wire (Terumo, RF-GA35403M Standard, 0.035 inch) was
pushed up and the esophageal obstruction was traversed,
which simultaneously was monitored by a transnasal
endoscope. Using a guiding catheter the esophageal sten-
osis was dilated and a naso-jejunal triluminal feeding
tube was placed into the first jejunal loop. Subsequently
the longitudinal duodenal incision was closed in a trans-
verse fashion. Before closure of the abdominal wall a jeju-
nostomy catheter was implanted to ensure sufficient
enteral nutrition. 72 hours later, in a second step further
endoscopic guided dilatation of the esophageal stenosis
was repeated twice. Using a stiff wire (0.035 inch) placed
under fluoroscopic control subsequent guide wired dilata-
tion, up to 12.8 mm according to the method of Savary,
was performed. In a third step a nitinol self-expanding
fully covered stent, the so called Choo stent (M.I. Tech/
MTW), was placed across the fistula under radiological
and endoscopic control (Figure 4). After successful place-
ment of the stent the upper end was located directly prox-
imal from the stenosis at about 20 cm from frontal
incisors and completely traversed the whole stenosis. As a
result the patient felt neither foreign body sensation nor
pain. A follow up contrast study, performed on the 4th day
after stent placement, showed the stent to be almost com-
pletely expanded without any signs of persisting leakage.
Thereafter the patient was allowed to swallow liquid food,
although only a small volume could be swallowed at a
time. A few days later swallowing of semi solids and
hypercaloric liquid food was possible and the patient was
discharged.
Follow-up analyses revealed that the patient died 158
days after our treatment due to severe pleural effusion and
diffuse pulmonary metastasis.
Discussion
In patients with malignant esophageal obstruction and
esophago-respiratory fistulae oral intake is limited by par-
Axial contrast enhanced CT image showed a mediastinal tumor wi h mediastinal air and  perf ration of the tracheal wall (arrow)Figure 1
Axial contrast enhanced CT image showed a mediastinal 
tumor with mediastinal air and a perforation of the tracheal 
wall (arrow).Page 2 of 4
(page number not for citation purposes)
World Journal of Surgical Oncology 2008, 6:8 http://www.wjso.com/content/6/1/8oxysmal coughing, leading to profound malnutrition and
death from recurrent pulmonary infections. Closure of the
esophago-respiratory fistulae is the predominant goal of
palliative therapy in this situation. Endoscopic placement
of a covered expandable metallic stent is a well established
minimal invasive approach [6]. In most cases stent place-
ment begins with a transoral passage of a guide wire
through the esophageal stenosis. Sophisticated utilization
of angiographic techniques with catheters and guide wires
enables dilatation even of high grade esophageal stenoses.
However in cases with complete obstruction and associ-
ated fistulae stenoses often remain impassable, because
the guide wire constantly enters the wrong lumen of the
Nitinol self expanding stent placed within the esophageal cav-ity (arrow)Figu e 4
Nitinol self expanding stent placed within the esophageal cav-
ity (arrow).
Retrograde endoscopic access to the esophageal lumen was ob ained by open surgery and a duoden tomyFigur  3
Retrograde endoscopic access to the esophageal lumen was 
obtained by open surgery and a duodenotomy.
Gastrographin contrast swallow showed that oral contrast medium has entered the left sided tracheobronchial system (arrow)Figu e 2
Gastrographin contrast swallow showed that oral contrast 
medium has entered the left sided tracheobronchial system 
(arrow).Page 3 of 4
(page number not for citation purposes)
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fistula. Recently a new technique with retrograde passage
of the stenotic segment has been described [7,8] and suc-
cessfully applied in several centers [4,9-11]. In all cases a
percutaneous gastric puncture was performed and an
endoscope was directed into the distal esophagus ena-
bling retrograde dilatation. Unfortunately this technique
does not apply to those patients who initially underwent
esophageal resection and subsequent interposition of a
gastric tube. In our view postoperative adhesions and
adjacent loops as well as the location of the small residual
stomach clearly impede percutaneous punction in these
patients. Even radiologically guided techniques for percu-
taneous punction are extremely difficult and pose a high-
risk of perforation. Therefore we performed open surgery,
identified the duodenum and entered an endoscope
through a spare longitudinal incision. Via the gastric tube
a guide wire was pushed up and the esophageal obstruc-
tion was traversed for subsequent stent placement.
In patients with esophageal carcinoma local recurrence as
well as ERF are frequently observed, despite of radical sur-
gery and adjuvant radio-chemotherapy. If transoral pas-
sage and stent placement is not possible, these patients
urgently need alternative approaches for successful pallia-
tion. Due to the interposition of a gastric tube, postopera-
tive anatomy is complex and retrograde endoscopy via a
percutaneous gastrostomy has not been described in the
current literature.
Conclusion
In our view open surgery is a safe means to access the gas-
tric tube via a duodenal incision, enabling retrograde
endoscopic dilatation of the obstructed segment as well as
simultaneous implantation of a jejunostomy catheter for
sufficient enteral nutrition. This approach should be con-
sidered for high grade esophageal obstruction and ERF,
when antegrade passage of the lumen is not possible. Sur-
gery is warranted even if retrograde esophageal passage
might fail, because open implantation of a jejunostomy
catheter for enteral nutrition remains the only and ulti-
mate palliative option in this situation.
Competing interests
The author(s) declare that they have no competing inter-
ests.
Authors' contributions
RA: Reviewed the current literature, drafted the manu-
script and made substantial intellectual contributions to
the article; CK:Initiated the publication of this case,
helped to draft the manuscript and revised it critically;
SM:Performed the endoscopic procedures, helped to draft
the manuscript and revised it critically. KP: Performed the
X-ray examinations and supplied digital artwork. RMA:
Performed endoscopic procedures and helped in drafting
the manuscript; IÖ: Participated in the design of this arti-
cle and coordinated and helped to draft the manuscript.
KWT: Performed the surgical treatment of the patients,
helped to draft the manuscript and revised it critically.
All authors read and approved the manuscript.
Acknowledgements
Written consent was obtained from the patient for publication of this case 
report.
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Abstract Background Malignant esophageal stenosis with complete obstruction and esophagorespiratory fistula (ERF) is difficult to treat with standard endoscopic techniques. Case presentation We report a patient in whom with local recurrence of esophageal carcinoma an esophagotracheal fistula occurred. Initially the patient had undergone esophageal resection with interposition of a gastric tube. Due to complete obstruction of the lumen by recurrent tumor conventional transoral stent placement failed. For retrograde dilatation a laparotomy was performed. Via a duodenal incision endoscopic access to the gastric tube was achieved. Using a guidewire the esophageal obstruction was traversed and dilated. Then it was possible to place an esophageal stent via an antegrade approach. Conclusion Open surgery enables a safe access for retrograde endoscopic therapy in patients who had undergone esophageal resection with gastric interposition.</p

Iskender Özcan

Kröpil Patrick

Renter Marc A

Schmitt Marcus

Cupisti Kenko

Rehders Alexander

Knoefel Wolfram T

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World Journal of Surgical Oncology

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Camuñez F: Treatment of malignant esophagoresiratory fistulas with covered stents. Abdom Imaging

Endoscopic retrograde dilation of completely occlusive esophageal strictures. Ann Thorac Surg

Kochman ML: Technique of endoscopic retrograde puncture and dilatation of total esophageal stenosis in patients with radiationinduced strictures. Head Neck

Retrograde approach to pharyngo-esophageal obstruction. Gastrointest Endosc

SM: Pattern of recurrence following radical oesophagectomy with two-field lymphadenectomy.

Smolle-Jüttner FM: Successful endoscopical sealing of malignant esophagotracheal fistulae by using a covered self expandable sententing system. Eur J Cardiothorac Surg

Sugarbaker DJ: Combined antegrade and retrograde dilation: A new endoscopic technique in the management of complex esophageal obstruction. Gastrointest Endosc

Sung KB: Esophagorespiratory fistula: long-term results of palliative treatment with covered expandable metallic stents in 61 patients. Radiology

Surendran R: Role of retrograde dilation in the management of pharyngo-esophageal corrosive strictures. Dis Esophagus

Takaki H: Cervical oesophageal stent placement via a retrograde transgastric route.

Wong Kee Song LM, Larson MV: Endoscopic management of radiation-induced complete upper esophageal obstruction with an antegraderetrograde rendevous technique. Gastrointest Endosc

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Laparotomy enables retrograde dilatation and stent placement for malignant esophago-respiratory fistula

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