Enkvetchakul, D.

Nichols, C.G.

English

PubMed

D. Enkvetchakul

C.G. Nichols

Crossref

Gating Mechanism of KATP Channels

Enkvetchakul, Decha

NIchols, Colin G

Digital Commons@Becker

Gating Mechanism of KATP Channels: Function Fits Form

480 Gating Mechanism of Kir (KATP)

A family of putative Kir potassium channels in prokaryotes. BMC Evol. Biol. 1:14.T h e J o u r n a l o f G e n e r a l P h y s i o l o g y

A quantitative description of membrane current and its application to conduction and excitation in nerve.

Activation of inwardly rectifying K channels by distinct PtdIns(4,5)P2 interactions.

Activation of Shaker potassium channels. III. An activation gating model for wild-type and V2 mutant channels.

Adenosine 5 -triphosphate-sensitive potassium channels.

Adenosine triphosphate-sensitive potassium channels in the cardiovascular system.

Allosteric voltage gating of potassium channels I. Mslo ionic currents in the absence of Ca(2 ).

Anionic phospholipids activate ATP-sensitive potassium channels.

Association and stoichiometry of K(ATP) channel subunits.

ATP binding properties of the nucleotide-binding folds of SUR1.

ATP dependence of KATP channel kinetics in isolated membrane patches from rat ventricle.

ATP inhibition of KATP channels: control of nucleotide sensitivity by the N-terminal domain of the Kir6.2 subunit.

ATP interaction with the open state of the K(ATP) channel.

ATP4 mediates closure of pancreatic beta-cell ATP-sensitive potassium channels by interaction with 1 of 4 identical sites.

Blocker protection in the pore of a voltage-gated K channel and its structural implications.

Blocker state dependence and trapping in hyperpolarization-activated cation channels: evidence for an intracellular activation gate.

Burst kinetics of co-expressed Kir6.2/SUR1 clones: comparison of recombinant with native ATP-sensitive K channel behavior.

Conformational changes in S6 coupled to the opening of cyclic nucleotide-gated channels.

Control of rectiﬁcation and gating of cloned KATP channels by the Kir6.2 subunit.

Cooperative binding of ATP and MgADP in the sulfonylurea receptor is modulated by glibenclamide.

Correlating structure and function in ATP-sensitive K channels. Trends Neurosci.

Coupling between voltage sensor activation, Ca2 binding and channel opening in large conductance (BK) potassium channels.

Coupling G -dependent activation to channel opening via pore elements in inwardly rectifying potassium channels.

Crystal structure and mechanism of a calcium-gated potassium channel.

Different binding properties and afﬁnities for ATP and ADP among sulfonylurea receptor subtypes, SUR1, SUR2A, and SUR2B.

Direct activation of inward rectiﬁer potassium channels by PIP2 and its stabilization by Gbetagamma.

Direct photoafﬁnity labeling of the Kir6.2 subunit of the ATP-sensitive K channel by 8-azidoATP.

Distinct histidine residues control the acid-induced activation and inhibition of the cloned katp channel.

Distinct speciﬁcities of inwardly rectifying K( ) channels for phosphoinositides.

Dynamic interaction of S5 and S6 during voltage-controlled gating in a potassium channel.

Gated access to the pore of a voltage-dependent K channel.

Gating dependence of inner pore access in inward rectiﬁer K( ) channels.

Gating mechanism of BK (Slo1) channels: so near, yet so far.

Gating mechanisms: kinetic thinking. In Ion Channels of Excitable Membranes. Sinauer Associates,

Gating properties of inward-rectiﬁer potassium channels: effects of permeant ions.

Hydrolyzable ATP and PIP(2) modulate the small-conductance K( ) Channel in apical membranes of rat cortical-collecting duct (CCD).

Inactivation of the potassium conductance and related phenomena caused by quaternary ammonium ion injection in squid axons.

KATP channel inhibition by ATP requires distinct functional domains of the cytoplasmic C terminus of the pore-forming subunit.

Kinetics of ATP-sensitive K channel revealed with oil-gate concentration jump method.

Ligand-insensitive state of cardiac ATP-sensitive K channels. Basis for channel opening.

Localization of the activation gate for small conductance Ca2 - activated K channels.

Mapping of the physical interaction between the intracellular domains of an inwardly rectifying potassium channel,

Membrane phospholipid control of nucleotide sensitivity of KATP channels.

Modulation of rat atrial G protein-coupled K channel function by phospholipids.

Molecular analysis of ATP-sensitive K channel gating and implications for channel inhibition by ATP.

Molecular determinants of KATP channel inhibition by ATP.

Multiple sites of interaction between the intracellular domains of an inwardly rectifying potassium channel,

Mutations within the P-loop of Kir6.2 modulate the intraburst kinetics of the ATP-sensitive potassium channel.

Nucleotides and phospholipids compete for binding to the C terminus of KATP channels.

of the ATP-sensitive channel in channel inhibition by ATP.

On the nature of allosteric transitions: a plausible model.

Open state destabilization by ATP occupancy is mechanism speeding burst exit underlying KATP channel inhibition by ATP.

Permeant ion-dependent changes in gating of Kir2.1 inward rectiﬁer potassium channels.

Phosphatidylinositol 4,5-bisphosphate (PIP2) modulation of ATP and pH sensitivity in Kir channels. A tale of an active and a silent PIP2 site in the N terminus.

Phosphoinositides decrease ATP sensitivity of the cardiac ATP-sensitive K( ) channel. A molecular probe for the mechanism of ATP-sensitive inhibition.

PIP(2) activates KCNQ channels, and its hydrolysis underlies receptor-mediated inhibition of M currents.

PIP2 and PIP as determinants for ATP inhibition of KATP channels.

Probing ion permeation and gating in a K channel with backbone mutations in the selectivity ﬁlter.

Protons activate homomeric kir6.2 channels by selective suppression of the long and intermediate closures.

Receptor-mediated hydrolysis of plasma membrane messenger PIP2 leads to K -current desensitization.

Regulation of ROMK1 channel by protein kinase A via a phosphatidylinositol 4,5-bisphosphate-dependent mechanism.

Scanning the intracellular s6 activation gate in the shaker k(

Sequence of events underlying the allosteric transition of rod cyclic nucleotide-gated channels.

Shaker potassium channel gating. III: Evaluation of kinetic models for activation.

Single channel studies of inward rectiﬁer potassium channel regulation by muscarinic acetylcholine receptors.

Speciﬁcity of activation by phosphoinositides determines lipid regulation of Kir channels.

State-dependent modiﬁcation of ATP-sensitive K channels by phosphatidylinositol 4,5-bisphosphate.

Structural and functional determinants of conserved lipid interaction domains of inward rectifying kir6.2 channels.

Structural determinants of gating in inward-rectiﬁer K channels.

Structural determinants of PIP(2) regulation of inward rectiﬁer K(ATP) channels.

Subunit stoichiometry of the pancreatic beta-cell ATP-sensitive K channel.

Subunit-dependent assembly of inward-rectiﬁer K channels.

The carboxyl termini of K(ATP) channels bind nucleotides.

The I182 region of k(ir)6.2 is closely associated with ligand binding in K(ATP) channel inhibition by ATP.

The kinetic and physical basis of K(ATP) channel gating: toward a uniﬁed molecular understanding.

The ligand-sensitive gate of a potassium channel lies close to the selectivity ﬁlter.

The open pore conformation of potassium channels.

The role of NH(2)-terminal positive charges in the activity of inward rectiﬁer K(ATP) channels.

The structure of the potassium channel: molecular basis of K conduction and selectivity.

The subunits of G proteins gate a K( ) channel by pivoted bending of a transmembrane segment.

Tight steric closure at the intracellular activation gate of a voltage- gated k( ) channel.

Trapping of organic blockers by closing of voltage-dependent K channels - evidence for a trap door mechanism of activation gating.

Truncation of Kir6.2 produces ATP-sensitive K channels in the absence of the sulphonylurea receptor.

Voltagecontrolled gating at the intracellular entrance to a hyperpolarization-activated cation channel.

Where is the activation gate for PIP2 gating of Kir2.1 channels?

Yeast screen for constitutively active mutant G protein-activated potassium channels.

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Gating Mechanism of KATP Channels: Function Fits Form

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