Induction of innate cytokine responses by respiratory mucosal challenge with R848 in zebrafish, mice, and humans.

Authors
Publication date
3 April 2019
Publisher
J Allergy Clin Immunol
Doi

    Abstract

    We compared live zebrafish, mouse and human nasal challenge responses to the TLR7/8 agonist resiquimod (R848). We found remarkably similar induction of mediators in the three species, offering novel mucosal models of innate anti-viral immunity

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