IN VITRO STUDIES OF MAMMALIAN SOMATIC CELL VARIATION : I. DETECTION OF H-2 PHENOTYPE IN CULTURED MOUSE CELL LINES

Abstract

The isoantigenic phenotype of the H-2 locus has been detected by isohemagglutinin absorption in a line of mouse lymphoma cells growing continuously in culture for 6 years and in two established lines of fibroblastic mouse cells growing continuously in culture for 1 year. Quantitative absorption studies suggest that the concentration of H-2 isoantigens is higher in the cultured lymphoma cells than in the other two fibroblastic cell lines

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