This work presents the first in-vivo High-frame rate Contrast Enhanced Ultrasound (HFR CEUS) for cardiac application. The in-vivo acquisition has been made on a sheep. A coherent compounding of diverging waves combined with Pulse Inversion (PI) transmission allow a frame rate of 250 frame per seconds which is 8 times faster than standard CEUS acquisition in cardiac application. The proposed method improves the image contrast compared to the CEUS and allows a better tracking of fast movement of the heart