Combining nanoceria and fulleropyrrolidine in a tethered nanosystem allows for efficient scavenging of reactive oxygen species and improved protection of mouse fibroblast cells exposed to a UV insult

Alessandra Pinna

Eleonora Cali

Grazia Galleri

Gwilherm Kerherve

Luca Malfatti

Michele Maggini

Plinio Innocenzi

Nanoscale Advances

English

PubMed

Dual-tethered nanosystems which combine different properties at the nano scale represent a new fascinating frontier of research. In the present work, we present an example of a dual nanosystem designed to enhance the radical scavenging performances. Fulleropyrrolidine has been bonded to cerium oxide nanoparticles (nanoceria) to form a dual tethered system. Fulleropyrrolidine, bearing a silyl-alkoxide group, has been chemically bonded to the nanoceria surface, providing unprecedented antioxidant activity. This effect has been evaluated using an L929 mouse fibroblast cell line exposed to UV light. The fulleropyrrolidine molecules tethered to nanoceria enhance the radical scavenging properties of the oxide. At the same time, fulleropyrrolidine mitigates the potential toxicity of nanoceria at high doses. On the other hand, cerium oxide nanoparticles provide a strong hydrophilicity to the dual nanosystem, ensuring the administration in a cellular environment and preventing macroscopic aggregation of fulleropyrrolidine. The rational assembly of two different components in one nanosystem appears as a promising route for the development of “smarter” medical and cosmetic devices

Pinna, Alessandra

Cali, Eleonora

Kerherve, Gwilherm

Galleri, Grazia

Maggini, Michele

Innocenzi, Plinio

Malfatti, Luca

PubMed Central

Fulleropyrrolidine-functionalized ceria nanoparticles as a tethered dual nanosystem with improved antioxidant properties

Fulleropyrrolidine-functionalized ceria nanoparticles as a tethered dual nanosystem with improved antioxidant properties

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