We studied sex-linked differences and aging-dependent changes of the clinical reference range (CCR) calculated from routine chemical laboratory data with analyzing histogram of data. CCR of γ-GTP, UA and Cr was higher in males than in females. CCR of ALP was about three-fold higher in adolescents than in adults. Aging-dependent increase was found
on CCR of AMY, LDH and BUN. CCR of GPT, ChE and AMY, LDH and BUN. CCR of GPT, ChE and UA was elevated in males in the age group of 30-60. CCR of γ-GTP was elevated in males in the age group of 50-60. Frequency curve of the data in TP, Alb, A/G ratio, Na, Cl, Ca, IP and Mg showed normal distribution, and that of the data in T-Bil, I-Bil, ALP, AMY, LDH, ChE, TC, TG, PL, BUN, UA, Cr and K showed log-normal distribution. We discuss these results and establish the CCR for clinical use
