Peritoneal dissemination is a special condition of gastric cancer metastasis, which worsens the quality of patients' lives and is often difficult to control. In this study, we describe the basic features of the peritoneal dissemination of gastric cancer. Some molecular events are associated with the peritoneal dissemination, including c-met gene amplification, chromosome 7q deletion, and Reg Ⅳ overexpression. Especially, Reg Ⅳ overexpression enhances the antiapoptotic property of gastric cancer cells. In contrast, activation of PPARg inhibits the peritoneal dissemination by the pro-apoptotic effect
