Postprandial hyperglycemia is a better predictor of cardiovascular disease and all cause mortality than fasting blood glucose or hemoglobin A1c. Physical inactivity is associated with insulin resistance and cardiovascular disease. To determine whether transitioning from a high to low level of physical activity affects glycemic control, we equipped young (30 [plus or minus] 1 y), lean (24 [plus or minus] 1 kg-m-2), healthy, physically active (>10,000 steps-d-1) volunteers (N=10) with continuous blood glucose monitors for 3 days during separate ACTIVE (habitual physical activity) and INACTIVE ([less than or equal to]5,000 steps-d-1) phases (diet replicated across phases)
