In the wake of the research that values Chemistry teaching and learning promoter of scientific literacy we developed under the EANCYT Project (Enseñanza y Aprendizaje sobre la Naturaleza de la Ciencia y Tecnología) a didactic sequence in order to improve students’ understanding of the interdependence between Science and Technology through explicit teaching about the nature of science. In the design of the didactic sequence were used materials framed in the sphere of the History of Science, linked to the name of Antoine Laurent Lavoisier, frequently considered as the father of Chemistry. These documents illustrate a remarkable episode in the evolution of this experimental science, in which the design and use of a complex technological device allowed the synthesis of water from hydrogen and oxygen reaching the proportions in which we now know that these gases combine. Are analyzed and presented some results obtained from the answers to some questions of COCTS (Cuestionario de Opiniones sobre Ciencia, Tecnologia y Sociedad), using a research methodology with pre-test/post-test and control group to evaluate both students and the didactic sequence