Alzheimer’s disease (AD) is the most common form of dementia and causes a progressive and irreversible neurodegeneration. It is related
with loss of cholinergic function, which affects memory, learning and behavior [1]. Neurophathologically, AD is characterized by the presence
of beta-amyloid plaques (A ) and neurofibrillary tangles (NFT) [2] and consequent degeneration of the basal forebrain cholinergic neurons
[3]. The loss of cholinergic neurons leads to the progressive reduction of acetylcholine (ACh) in the brain and resulting cognitive impairment
in AD [3]. As such, the enzyme acetylcholinesterase (AChE) has been one of the prime targets in search for a treatment for AD, which uses
reversible inhibitors of AChE, in order to increase levels of acetylcholine (ACh) in the brain [4].
In the present study a small library of quinolinone and indole derivatives was screened for their eeAChE inhibitory activity using the Ellman
method
