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Fulminant candidemia diagnosed by prompt detection of pseudohyphae in a peripheral blood smear
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Abstract
A 77-year-old man treated with prednisolone for pemphigus developed severe sepsis
by Pseudomonas aeruginosa and methicillin-resistant Staphylococcus aureus. Several
antibiotics were administered. A peripheral blood smear showed growth of a large
number of yeast extending pseudohyphae which could be seen both inside and outside
of leucocytes. Antifungal agents were added immediately, however, he did not recover.
Several days later, blood culture showed Candida albicans septicemia. The autopsy
revealed microabscesses in the lung, heart, liver and kidney. A large amount of
neutrophil invasion and yeast with peudohypae were also detected