US7323303; US7323303 B2; US7323303B2; US7,323,303; US7,323,303 B2; 7323303; Application No. 10/401,867Inventor name used in this publication: Thomas Yun-Chung LeungInventor name used in this publication: Pak-Ho ChanUSVersion of Recor

Chan, PH

Leung, TYC

Wong, KY

PolyU Institutional Repository

Modified β-lactamases and uses thereof

A tool that can screen bacteria for β-lactamases against a panel of various antibiotics is desirable. A biosensor incorporating an indicator molecule into β-lactamases may achieve this purpose, but it requires that the attached indicator molecule must not impair the binding affinity of the protein to a great extent to provide a higher sensitivity. A modified β-lactamases with a residue on the Ω-loop or outside the Ω-loop but close to the active site of β-lactamase being replaced by a reactive residue is developed in this invention.Department of Applied Biology and Chemical TechnologyUS7323303; US7323303 B2; US7323303B2; US7,323,303; US7,323,303 B2; 7323303; Application No. 10/401,867Inventor name used in this publication: Thomas Yun-Chung LeungInventor name used in this publication: Pak-Ho ChanU

Modified β-lactamases and uses thereof

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