Frederiksen, Marie

Knudsen, Lisbeth E.

Nielsen, Jesper Bo

Sørensen, Lars Schiøtt

Thomsen, Marianne

Vorkamp, Katrin

Besides diet, house dust has been recognized as an important exposure media for polybrominated diphenyl ethers (PBDEs) [1]. Our previous work showed significant associations between levels in dust and in human plasma, for the congeners BDE-28, BDE-47 and BDE-100 as well as for ΣPBDEtri hexa [2]. Recent results from Sweden indicated that dust was a significant source of exposure for the octa- to decabrominated congeners in particular [3]. Moreover, several novel flame retardants (NFRs) have been detected in dust some of which might be replacement products of PBDEs [4]. Building on these findings, the objectives were to study whether i) the associations observed for plasma also existed for human milk, ii) the PBDE profiles in dust and milk could provide insights into the bioavailability and bioaccumulation of individual congeners, iii) NFRs were measurable in human milk, and iv) infants were exposed to significant amounts of NFRs via breast feeding. PBDEs were detected in all of the 40 milk samples analysed in this study. ΣPBDEtri-hepta ranged from 0.98-45.8 ng/g lw, with a median of 2.26 ng/g lw. The main congener in milk was BDE-153, accounting for 35% of ΣPBDEtri-hepta. This is much higher than in dust collected in the same residences, but comparable to plasma and placenta [2,5]. BDE-99 on the other hand, had clearly lower percentages in human milk than in dust. BDE-209 had a median concentration of 0.64 ng/g lw, which was similar to that of BDE-47 and confirmed that BDE-209 was taken up by humans and, despite its shorter half-life, accumulates to the extent that exposure of infants can occur.As for plasma, PBDE-levels in milk samples were significantly correlated with dust levels (Spearman rank), this was most pronounced for the lower brominated congeners like BDE-28 (p=0.03) and 47 (p=0.006). Large intercorrelation was also observed, e.g. BDE-47 in milk was significantly correlated with most other congeners, though not with BDE-209. In contrast to the plasma results, significant correlation of BDE-99 in milk and dust was also observed (p=0.003). One explanation for this may be the higher detection frequency of BDE-99 in milk compared with plasma (100% vs. 37%).Hexabromocyclododecane and the NFRs bis(2-ethylhexyl)tetrabromophthalate (BEH-TEBP), 2-ethylhexyl-2,3,4,5-tetrabromobenzoate (EH-TBB), 1,2-bis(2,4,6-tribromophenoxy)-ethane (BTBPE), decabromodiphenyl ethane (DBDPE), 2,3-dibromopropyl-2,4,6-tribromophenyl ether (TBP-DBPE) and dechlorane plus (DDC-CO) have been detected in the same dust samples previously analysed for PBDEs and are currently being analysed in the corresponding human milk samples.[1] Stapleon H.M., Eagle S., Sjödin A., Webster T.F. (2012). Serum PBDEs in a North Carolina Toddler Cohort: Associations with handwipes, house dust, and socioeconomic variables. Environ. Health Perspect. 120, 1049-1054. [2] Frederiksen M., Thomsen C., Frøshaug M., Vorkamp K., Thomsen M., Becher G., Knudsen L.E. (2010). Polybrominated diphenyl ethers in paired samples of maternal and umbilical cord blood plasma and associations with house dust in a Danish cohort. Int. J. Hyg. Environ. Health 213, 233-242.[3] Sahlström L.M.O., Sellström U., de Wit C.A., Lignell S., Darnerud P.O. (2015). Estimated intakes of brominated flame retardants via diet and dust compared to internal concentrations in a Swedish mother-toddler cohort. Int. J. Hyg. Environ. Health 218, 422-432.[4] Ali N., Harrad S., Goosey E., Neels H., Covaci A. (2011). “Novel” brominated flame retardants in Belgian and UK indoor dust: Implications for human exposure. Chemosphere 83, 1360-1365.[5] Vorkamp K., Thomsen M., Frederiksen M., Pedersen M., Knudsen L.E. (2011). Polybrominated diphenyl ethers (PBDEs) in the indoor environment and associations with prenatal exposure. Environ. Int. 37, 1-10.<br/

VBN (Videnbasen)  Aalborg Universitets forskningsportal

    Aalborg UniversitetPolybrominated diphenyl ethers and novel flame retardantsFrederiksen, Marie; Vorkamp, Katrin; Nielsen, Jesper Bo; Sørensen, Lars Schiøtt; Thomsen,Marianne; Knudsen, Lisbeth E.Publication date:2016Document VersionEarly version, also known as pre-printLink to publication from Aalborg UniversityCitation for published version (APA):Frederiksen, M., Vorkamp, K., Nielsen, J. B., Sørensen, L. S., Thomsen, M., & Knudsen, L. E. (2016).Polybrominated diphenyl ethers and novel flame retardants: associations between dust and human milk.Abstract from DUST2016, Taranta, Italy.General rightsCopyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright ownersand it is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights.            ? Users may download and print one copy of any publication from the public portal for the purpose of private study or research.            ? You may not further distribute the material or use it for any profit-making activity or commercial gain            ? You may freely distribute the URL identifying the publication in the public portal ?Take down policyIf you believe that this document breaches copyright please contact us at vbn@aub.aau.dk providing details, and we will remove access tothe work immediately and investigate your claim.Downloaded from vbn.aau.dk on: May 01, 2017POLYBROMINATED DIPHENYL ETHERS AND NOVEL FLAME RETARDANTS: ASSOCIATIONS BETWEEN DUST AND HUMAN MILK MARIE FREDERIKSEN* (1), KATRIN VORKAMP (2), JESPER BO NIELSEN (3), LARS S. SØRENSEN (1), MARIANNE THOMSEN (2), LISBETH E. KNUDSEN (4) (1) Aalborg University, Danish Building Research Institute, 2450 Copenhagen SV, Denmark  (2) Aarhus University, Department of Environmental Science, 4000 Roskilde, Denmark (3) University of Southern Denmark, Environmental Medicine, Institute of Public Health, 5000 Odense C, Denmark (4) University of Copenhagen, Department of Public Health, 2100 Copenhagen Ø, Denmark  Besides diet, house dust has been recognized as an important exposure media for polybrominated diphenyl ethers (PBDEs) [1]. Our previous work showed significant associations between levels in dust and in human plasma, for the congeners BDE-28, BDE-47 and BDE-100 as well as for ΣPBDEtri hexa [2]. Recent results from Sweden indicated that dust was a significant source of exposure for the octa- to decabrominated congeners in particular [3]. Moreover, several novel flame retardants (NFRs) have been detected in dust some of which might be replacement products of PBDEs [4].   Building on these findings, the objectives were to study whether i) the associations observed for plasma also existed for human milk, ii) the PBDE profiles in dust and milk could provide insights into the bioavailability and bioaccumulation of individual congeners, iii) NFRs were measurable in human milk, and iv) infants were exposed to significant amounts of NFRs via breast feeding.   PBDEs were detected in all of the 40 milk samples analysed in this study. ΣPBDEtri-hepta ranged from 0.98-45.8 ng/g lw, with a median of 2.26 ng/g lw. The main congener in milk was BDE-153, accounting for 35% of ΣPBDEtri-hepta. This is much higher than in dust collected in the same residences, but comparable to plasma and placenta [2,5]. BDE-99 on the other hand, had clearly lower percentages in human milk than in dust. BDE-209 had a median concentration of 0.64 ng/g lw, which was similar to that of BDE-47 and confirmed that BDE-209 was taken up by humans and, despite its shorter half-life, accumulates to the extent that exposure of infants can occur.  As for plasma, PBDE-levels in milk samples were significantly correlated with dust levels (Spearman rank), this was most pronounced for the lower brominated congeners like BDE-28 (p=0.03) and 47 (p=0.006). Large intercorrelation was also observed, e.g. BDE-47 in milk was significantly correlated with most other congeners, though not with BDE-209. In contrast to the plasma results, significant correlation of BDE-99 in milk and dust was also observed (p=0.003). One explanation for this may be the higher detection frequency of BDE-99 in milk compared with plasma (100% vs. 37%).  Hexabromocyclododecane and the NFRs bis(2-ethylhexyl)tetrabromophthalate (BEH-TEBP), 2-ethylhexyl-2,3,4,5-tetrabromobenzoate (EH-TBB), 1,2-bis(2,4,6-tribromophenoxy)-ethane (BTBPE), decabromodiphenyl ethane (DBDPE), 2,3-dibromopropyl-2,4,6-tribromophenyl ether (TBP-DBPE) and dechlorane plus (DDC-CO) have been detected in the same dust samples previously analysed for PBDEs and are currently being analysed in the corresponding human milk samples.  [1] Stapleon H.M., Eagle S., Sjödin A., Webster T.F. (2012). Serum PBDEs in a North Carolina Toddler Cohort: Associations with handwipes, house dust, and socioeconomic variables. Environ. Health Perspect. 120, 1049-1054.  [2] Frederiksen M., Thomsen C., Frøshaug M., Vorkamp K., Thomsen M., Becher G., Knudsen L.E. (2010). Polybrominated diphenyl ethers in paired samples of maternal and umbilical cord blood plasma and associations with house dust in a Danish cohort. Int. J. Hyg. Environ. Health 213, 233-242. [3] Sahlström L.M.O., Sellström U., de Wit C.A., Lignell S., Darnerud P.O. (2015). Estimated intakes of brominated flame retardants via diet and dust compared to internal concentrations in a Swedish mother-toddler cohort. Int. J. Hyg. Environ. Health 218, 422-432. [4] Ali N., Harrad S., Goosey E., Neels H., Covaci A. (2011). “Novel” brominated flame retardants in Belgian and UK indoor dust: Implications for human exposure. Chemosphere 83, 1360-1365. [5] Vorkamp K., Thomsen M., Frederiksen M., Pedersen M., Knudsen L.E. (2011). Polybrominated diphenyl ethers (PBDEs) in the indoor environment and associations with prenatal exposure. Environ. Int. 37, 1-10. 

Polybrominated diphenyl ethers and novel flame retardants:associations between dust and human milk

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Polybrominated diphenyl ethers and novel flame retardants:associations between dust and human milk

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