Christiansen, Ole Bjarne

Sommer, Steffen

Steffensen, Rudi

Sundtoft, Iben

Uldbjerg, Niels

&lt;b&gt;&lt;i&gt;Objective:&lt;/i&gt;&lt;/b&gt; To study the association between cervical insufficiency and single nucleotide polymorphisms in seven genes coding for pro- and anti-inflammatory cytokine-related factors, mannose-binding lectin 2 &lt;i&gt;(MBL2)&lt;/i&gt;, collagen1α1 &lt;i&gt;(COL1A1)&lt;/i&gt;, &lt;i&gt;factor II&lt;/i&gt; and &lt;i&gt;factor V Leiden&lt;/i&gt; genes. &lt;b&gt;&lt;i&gt;Methods:&lt;/i&gt;&lt;/b&gt; In a case-control study, potential maternal biomarkers for cervical insufficiency were investigated in 30 women with a history of second-trimester miscarriage or preterm birth due to cervical insufficiency and in 70 control women. &lt;b&gt;&lt;i&gt;Results:&lt;/i&gt;&lt;/b&gt; Homozygous carriers of the interleukin 6 &lt;i&gt;(IL6)&lt;/i&gt; -174 genotype GG had an odds ratio (OR) of 3.1 [95% confidence interval (95% CI) 1.3-7.4, p = 0.01] and &lt;i&gt;MBL2&lt;/i&gt; genotypes coding for low or intermediate levels of plasma MBL had an OR of 3.3 (95% CI 1.2-9.0, p = 0.01) for cervical insufficiency compared with controls. Serum MBL levels were lower in women with cervical insufficiency than in controls (median 408 and 1,985 ng/ml, respectively, p &lt; 0.01). &lt;b&gt;&lt;i&gt;Conclusions:&lt;/i&gt;&lt;/b&gt; Single nucleotide polymorphisms in the &lt;i&gt;IL6&lt;/i&gt; gene and the &lt;i&gt;MBL2&lt;/i&gt; gene and low MBL levels related to the latter polymorphism may increase the risk of preterm birth due to cervical insufficiency.</jats:p

Iben Sundtoft

Niels Uldbjerg

Rudi Steffensen

Steffen Sommer

Ole Bjarne Christiansen

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Gynecologic and Obstetric Investigation

Polymorphisms in Genes Coding for Cytokines, Mannose-Binding Lectin, Collagen Metabolism and Thrombophilia in Women with Cervical Insufficiency

OBJECTIVE: To study the association between cervical insufficiency and single nucleotide polymorphisms in seven genes coding for pro- and anti-inflammatory cytokine-related factors, mannose-binding lectin 2 (MBL2), collagen1α1 (COL1A1), factor II and factor V Leiden genes.METHODS: In a case-control study, potential maternal biomarkers for cervical insufficiency were investigated in 30 women with a history of second-trimester miscarriage or preterm birth due to cervical insufficiency and in 70 control women.RESULTS: Homozygous carriers of the interleukin 6 (IL6) -174 genotype GG had an odds ratio (OR) of 3.1 [95% confidence interval (95% CI) 1.3-7.4, p = 0.01] and MBL2 genotypes coding for low or intermediate levels of plasma MBL had an OR of 3.3 (95% CI 1.2-9.0, p = 0.01) for cervical insufficiency compared with controls. Serum MBL levels were lower in women with cervical insufficiency than in controls (median 408 and 1,985 ng/ml, respectively, p &lt; 0.01).CONCLUSIONS: Single nucleotide polymorphisms in the IL6 gene and the MBL2 gene and low MBL levels related to the latter polymorphism may increase the risk of preterm birth due to cervical insufficiency. © 2015 S. Karger AG, Basel.</p

Polymorphisms in Genes Coding for Cytokines, Mannose-Binding Lectin, Collagen Metabolism and Thrombophilia in Women with Cervical Insufficiency

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