Morishita, Michiko

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Okayama University Scientific Achievement Repository

PLOS ONE Risk factors for cytomegalovirus infection in patients with antineutrophil cytoplasmicantibody-associated vasculitis--Manuscript Draft-- Manuscript Number: PONE-D-18-20504R1Article Type: Research ArticleFull Title: Risk factors for cytomegalovirus infection in patients with antineutrophil cytoplasmicantibody-associated vasculitisShort Title: Risk factors for CMV infection in AAV patientsCorresponding Author: Michiko Morishita"Okayama Daigaku Daigakuin Ishiyakugaku Sogo Kenkyuka Igakubu"Okayama, JAPANKeywords: anti-neutrophil cytoplasmic antibody-associated vasculitis;  cytomegalovirus;  riskfactors;  InfectionAbstract: Aims: Cytomegalovirus (CMV) infection under immunosuppression sometimes causesdeath. This study aimed to elucidate risk factors for CMV infection in patients withantineutrophil cytoplasmic antibody-associated vasculitis (AAV).Methods: Patients with AAV who underwent remission induction treatment at OkayamaUniversity Hospital between 2006 and 2016 were retrospectively analyzed. Theprimary outcome was the development of CMV infection within 3 months.Results: Of the 111 patients, 13 (11.7%) patients developed CMV infection. Patientswith CMV infection were older (p = 0.030) and had a higher body mass index (p =0.029) in comparison to those without CMV infection. A higher proportion had a severeform (p = 0.001) and granulomatosis with polyangiitis (GPA) (p = 0.001), as well as ahigher Birmingham Vasculitis Activity Score (p = 0.018) and C-reactive protein (p =0.018) levels at baseline. Using logistic regression analysis, severe form and GPAwere independent risk factors (odds ratio [OR] = 9.68, 95% confidence interval [CI] =1.92-60.23, and OR = 7.46, 95% CI = 1.46-47.60, respectively). In addition, patientswith CMV infection were more likely than those without infection to be glucocorticoid-related diabetes mellitus (p = 0.025).Conclusion: Our study highlights disease severity and subgroups of AAV as risk factorsfor CMV infection.Order of Authors: Michiko MorishitaKen-Ei SadaYoshinori MatsumotoKeigo HayashiYosuke AsanoSumie HiramatsuKeiji OhashiYoshia MiyawakiEri KatsuyamaHaruki WatanabeTomoko KawabataJun WadaOpposed Reviewers:Response to Reviewers: Reviewer: 11.How many treated patients with AAV were not tested for CMViraemia in the studyperiod? What criteria were used for testing for CMViraemia?Powered by Editorial Manager® and ProduXion Manager® from Aries Systems Corporation

ANCA関連血管炎患者におけるサイトメガロウイルス感染のリスク因子

http://ousar.lib.okayama-u.ac.jp/files/public/5/58417/20200515141946419748/K0006101_summary.pdf

ANCA関連血管炎患者におけるサイトメガロウイルス感染のリスク因子

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