SRIHARIKOTA acquired importance botanically because of rich Island vegetation and due to installation of Rocket Launching Station by Indian Space Research Organisation (ISRO). A few Tribal colonies are domiciled there. Some aged tribal men conversed with herbal medicines and practices. With a fear that this tribal medicinal knowledge of the island may be lost, if urgently not pursued in a recorded manner for the benefit of modern society, a project on Ethnobotany and tribal medicines of Sriharikota Island is taken up three years back in 1996. Regular field tours are conducted covering all the seasons and about 300 medicinal plants are collected along with ample field notes on folklore medicinal uses with the support of local aged tribal men. Out of these, a few plants are selected on the basis of endemism and utility and subjected to phytochemical analysis. Investigation for 11 chemical components is made in 21 samples. All the data is recorded in this paper. The results are mostly in conformity with the medicinal uses and they are discussed