The Eastern Ghats, one of the nine Floristic Zones in India. Eastern Ghats are spread over three States of India, namely Orissa, Andhra Pradesh and Tamil Nadu. The hilly areas of Eastern Ghats in Andhra Pradesh are mainly inhabited by 33 aboriginal/tribal communities, who still practice the age old traditional medicines and their application. There are 62 different tribes, inhabited in Orissa. The inhabitants of the aboriginal tribal communities, who still practice the age old traditional medicines and their applications. The author undertook ethno medicobotanical studies in Eastern Ghats along with systematic survey. Many tribal people depending on naturally growing or wild plants for their food and medicine in this region. The study during 1997-2005 brought to light, many unknown uses of plants which are interesting has been collected by the author. The present paper deals with some rare and endemic plant ethnobotanical uses of Eastern Ghats