Okuyama, Yuka

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Okayama University Scientific Achievement Repository

  2 Abstract 32 This study aimed to clarify the relationship between repeated measurements of casual (spot) 33 and 24-hour urinary sodium-to-potassium (Na/K) ratios in patients with chronic kidney 34 disease (CKD).  A total of 61 inpatients with CKD, 31 in stage 1-3 (eGFR [estimated 35 glomerular filtration rate] ≥ 30 ml/min/1.73m2) and 30 in stage 4-5 (eGFR<30 36 ml/min/1.73m2), aged 20 to 85 consuming a low-sodium diet (NaCl [sodium chloride] 6 37 g/day) were recruited. Urinary Na, K, and Na/K ratios were measured in both casual urine 38 samples and 2-day, 24-hour urine samples, and then analyzed by correlation and 39 Bland-Altman analyses.  Mean 24-hour urine Na/K ratio was higher in participants in stage 40 4-5 (5.1) than in participants in stage 1-3 (4.1) CKD. Casual urine Na/K ratio was strongly 41 correlated with 2-day, 24-hour urine Na/K ratio by sampling 4 casual urine specimens every 42 morning and evening in participants in stage 1-3 (r=0.69-0.78), but not in stage 4-5 43 (r=0.12-0.19). The bias for mean Na/K ratio between 2-day, 24-hour urine and the 4 casual 44 urine sampling ranged from -0.86 to 0.16 in participants in stage 1-3, and the quality of 45 agreement for the mean of this casual urine sampling was similar to that of sampling 8 casual 46 urine samples for estimating 2-day, 24-hour values. Methods using repeated casual urine 47 Na/K ratios may provide a reasonable estimation of 24-hour urine Na/K ratio in normotensive 48 and hypertensive as well as individuals with stage 1-3, but not stage 4-5 CKD. 49 (236 words) 50 51 

慢性腎臓病患者における複数回随時尿と24時間尿のナトリウム・カリウム比の関連性の検討

http://ousar.lib.okayama-u.ac.jp/files/public/6/60914/20201202104111161732/K0006237_summary.pdf

慢性腎臓病患者における複数回随時尿と24時間尿のナトリウム・カリウム比の関連性の検討

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