Aardestrup, Inge

Bjerregaard, Lone

Bülow, Rikke

Dethlefsen, Claus

Frøbert, Ole

Rasmussen, Jeppe

Schmidt, Erik

    Aalborg UniversitetPlasma triglycerides and apolipoprotein B levels are negatively correlated to flowmediated vasodilationBülow, Rikke; Aardestrup, Inge; Rasmussen, Jeppe; Dethlefsen, Claus; Frøbert, Ole;Bjerregaard, Lone; Schmidt, ErikPublication date:2006Document VersionPublisher's PDF, also known as Version of recordLink to publication from Aalborg UniversityCitation for published version (APA):Bülow, R., Aardestrup, I., Rasmussen, J., Dethlefsen, C., Frøbert, O., Bjerregaard, L., & Schmidt, E. (2006).Plasma triglycerides and apolipoprotein B levels are negatively correlated to flow mediated vasodilation. Postersession presented at XIV International Symposium on Atherosclerosis, Rom, Italy.General rightsCopyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright ownersand it is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights.            ? Users may download and print one copy of any publication from the public portal for the purpose of private study or research.            ? You may not further distribute the material or use it for any profit-making activity or commercial gain            ? You may freely distribute the URL identifying the publication in the public portal ?Take down policyIf you believe that this document breaches copyright please contact us at vbn@aub.aau.dk providing details, and we will remove access tothe work immediately and investigate your claim.Downloaded from vbn.aau.dk on: April 29, 2017PLASMA TRIGLYCERIDES AND APOLIPOPROTEIN B LEVELS ARE NEGATIVELY CORRELATED TO FLOW MEDIATED VASODILATIONObjectivesThe study aimed to determine flow mediated vasodilation (FMD), and correlate it to plasma lipids and lipoproteins. FMD was taken as a measure of endothelial function.MethodsFourty healthy subjects (20 women (10 premenopausal, 10 postmenopausal) and 20 men) were included. Mean age of  the premenopausal women was 40 years (range 26 to 51), postmenopausal women 58 years (range 54 to 66) and men 48 (range 24 to 62). The subjects were examined on two occasions, one month apart (same period of menstrual cycle in premenopausal women) in order to reduce variability. Blood samples were drawn after 10 hours of fasting and frozen at -80ºC until analysis in the same analytical run.FMD was determined after 15 minutes of rest with B-mode ultrasound of the right brachial artery after ischaemia (induced by a cuff inflated to 300 mmHg) for 5 min. Brachial artery FMD was calculated as a change in diameter from baseline to 60 seconds after cuff deflation expressed as a percentage increase from baseline. Average values of the measurements one month apart were read by the same experienced and blinded observer and used for calculation.Serum lipids and lipoproteins were measured by standard methods in the laboratory with LDL-cholesterol calculated by the Friedwald formula.Statistical methodsPearson’s correlation coefficient was used as a measure of association between FMD% and the serum lipids and lipoproteins. In the figures, the regression line with associated 95% confidence bands illustrate the linear relationship between FMD% and ApoB and triglycerides.ConclusionThere were significant negative correlations of FMD to triglycerides and ApoB. The study therefore suggests that plasma triglycerides and ApoB levels are correlated with impaired endothelial function in healthy subjects.ResultsThe sample mean and 95%CI of FMD in thepopulation was 9.6% [8.6;10.6].Mean [95% CI] Pearson correlation with FMD% [95% CI]p-value Total Cholesterol 5.2  [4.8;5.6] -0.26 [-0.53;0.05] 0.10HDL Cholesterol 1.4  [1.3;1.5]  0.20 [-0.12;0.48] 0.23LDL Cholesterol 3.2  [2.9;3.6] -0.26 [-0.53;0.06] 0.11Triglycerides 1.2  [1.0;1.4] -0.36 [-0.61;-0.06] 0.02ApoB 0.9  [0.8;1.0] -0.32 [-0.57;-0.01] 0.04Lp(a) 344 [192;497] -0.01 [-0.32;0.31] 0.97Serum lipids and lipoproteins were measured in mmol/L except for Lp(a) measured in IU/L and ApoB measured in g/L.AALBORG HOSPITALR.Bülow, BLS, I.V. Aardestrup, BLS,  J.G. Rasmussen, MD, C. Dethlefsen, MSc, O. Frøbert, MD, L.J. Bjerregaard, RD, E. B. Schmidt, MD. Dept. of Cardiology, Aalborg Hospital, Aarhus University Hospital, Denmark.

Plasma triglycerides and apolipoprotein B levels are negatively correlated to flow mediated vasodilation

http://vbn.aau.dk/files/4889029/Poster2.pdf

Plasma triglycerides and apolipoprotein B levels are negatively correlated to flow mediated vasodilation

Abstract

Similar works

Full text

Available Versions

VBN