Нами вивчалися oрганометричні параметри серця у молодих щурів при гіпоосмолярній гіпергідратації. Встановлено, що у молодих щурів під впливом гіпоосмолярної гіпергідратації  збільшується маса усіх камер серця та переважно розширюється порожнина правого шлуночка.Нами изучались органометрические параметры сердца у молодых крыс при гипоосмолярной гипергидратации. Установлено, что у молодых крыс под влиянием гипоосмолярной гипергидратации увеличивается масса всех камер сердца и преимущественно расширяется полость правого желудочка.We studied the organometric parameters of the heart in young rats at hypoosmolar overhydration. We found, that morphometric data of young rats under the influence of hypoosmolar  overhydration  show a uniform increasing in the mass of all chambers of the heart and the preferential expansion of the cavity of the right ventricle

Bumeister, Valentyna Ivanivna

Yarmolenkо, Olha Serhiivna

Бумейстер, Валентина Ивановна

Бумейстер, Валентина Іванівна

Ярмоленкo, Ольга Сергіївна

Ярмоленко, Ольга Сергеевна

Ярмоленко, Ольга Сергіївна

Yarmolenko, Olha Serhiivna

SocioEconomic Challenges Journal (Sumy State University)

Аnalysis of organometric data of myocardium in young rats at water 
intoxication 
О.S. Yarmolenko, V.I. Bumeyster, Department of Human Anatomy Medical Institute 
of Sumy State University  
Introduction. Оrgonometry gives the possibility to determine and compare the 
mass and the area of each chamber of the heart. 
Hypoosmolar overhydration often occurs when enteral introduction of a large 
quantity of water, acute renal failure, Parhon syndrome, eclampsia [2].  
The aim of this work was to study the organometric parameters of the heart in 
young rats at hypoosmolar overhydration.  
Materials and Methods. 
We used 12 three-month white laboratory male rats which were divided into 
experimental and control series. The experimental series included 6 animals,which 
received 10 ml distilled water through a tube three times a day and ate boiled 
demineralized food. To prevent physiological maintain of water homeostasis we 
injected synthetic analogue of antidiuretic hormone (vasopressin) "Mynyrin» 
(Ferring) twice daily at a dose of 0.01 mg. The severe overhydration was achieved on 
15th day [3].  The control group consisted of 6 rats which were injected with 
"Mynyrin» (Ferring) twice daily at a dose of 0.01 mg, considering the potential 
effects of vasopressin on the cardiovascular system. Animals received normal 
drinking water and food. 
We determined the net weight of the heart; the weight of  both ventricles and 
atria, Fulton index (the ratio of the mass of the left ventricle with interventricular 
septum  in weight of the right ventricle), ventricular index (the ratio of the mass of 
the left ventricle in weight of the right ventricle); area of the left and right ventriclar 
endocardial surfaces; planimetric index  (the ratio of the area of the left ventricular 
endocardial surfaces to the area of the right ventricular  endocardial surface) [1].  
Results and discussion.The net weight of the heart compared to control 
animals significantly increases by 26,83%( p<0,0001). The weight of left ventricle 
increases by 28,65%( p<0,0001), right ventricle – by 25,77%( p<0,0001), atria – by  
21,98%( p<0,0001). The relative gravity values (Fulton index and ventricular index) 
do not change during the experiment, indicating a uniform increasing in ventricular 
mass. The area of endocardial surface of the left ventricle does not change 
significantly, while the same indicator of the right ventricle increases by 18,05% 
(p=0,0099).Planimetric index reduces by 8,78%( p<0,0001).  
Conclusions. Сhanges morphometric data of young rats under the influence of 
hypoosmolar  overhydration  are characterized by a uniform increase in the mass of 
all chambers of the heart and the preferential expansion of the cavity of the right 
ventricle. 
 
References: 
 1. Avtandilov G.G.  Fundamentals of quantitative pathological anatomy / 
G.G. Avtandilov - M.: Medicine, 2002. - 240 p. 
         2. Hanonh V.F.  Human Physiology / William F. Hanonh - Lviv, 2002. - 
P.669-678 . 
 3. Methods of experimental reproduction of fluid and electrolyte 
disorders / V.Z. Sikora, G.F. Tkach , V.I. Bumeyster [ et al. ] / Proceedings of the 
conference "The morphological state of tissues and organs of the body in health and 
disease", Ternopil 10-11
th 
of June 2009, P. 160-161 . 
 
Yarmolenko O.S. Analysis of organometric data of myocardium in young rats 
at water intoxication / O.S. Yarmolenko, V.I. Bumeister // International scientific and 
practical conference "Perspective trends in scientific research – 2015", 17th - 22th of 
October 2015: Materials of International scientific and practical conference. – Vol. 2, 
Bratislava, Slovac Republic. – 2015. – P. 144-145. 


English

Analysis of organometric data of myocardium in young rats at water intoxication

Electronic Sumy State University Institutional Repository

Аnalysis of organometric data of myocardium in young rats at water intoxication О.S. Yarmolenko, V.I. Bumeyster, Department of Human Anatomy Medical Institute of Sumy State University  Introduction. Оrgonometry gives the possibility to determine and compare the mass and the area of each chamber of the heart. Hypoosmolar overhydration often occurs when enteral introduction of a large quantity of water, acute renal failure, Parhon syndrome, eclampsia [2].  The aim of this work was to study the organometric parameters of the heart in young rats at hypoosmolar overhydration.  Materials and Methods. We used 12 three-month white laboratory male rats which were divided into experimental and control series. The experimental series included 6 animals,which received 10 ml distilled water through a tube three times a day and ate boiled demineralized food. To prevent physiological maintain of water homeostasis we injected synthetic analogue of antidiuretic hormone (vasopressin) "Mynyrin» (Ferring) twice daily at a dose of 0.01 mg. The severe overhydration was achieved on 15th day [3].  The control group consisted of 6 rats which were injected with "Mynyrin» (Ferring) twice daily at a dose of 0.01 mg, considering the potential effects of vasopressin on the cardiovascular system. Animals received normal drinking water and food. We determined the net weight of the heart; the weight of  both ventricles and atria, Fulton index (the ratio of the mass of the left ventricle with interventricular septum  in weight of the right ventricle), ventricular index (the ratio of the mass of the left ventricle in weight of the right ventricle); area of the left and right ventriclar endocardial surfaces; planimetric index  (the ratio of the area of the left ventricular endocardial surfaces to the area of the right ventricular  endocardial surface) [1].  Results and discussion.The net weight of the heart compared to control animals significantly increases by 26,83%( p<0,0001). The weight of left ventricle increases by 28,65%( p<0,0001), right ventricle – by 25,77%( p<0,0001), atria – by  21,98%( p<0,0001). The relative gravity values (Fulton index and ventricular index) do not change during the experiment, indicating a uniform increasing in ventricular mass. The area of endocardial surface of the left ventricle does not change significantly, while the same indicator of the right ventricle increases by 18,05% (p=0,0099).Planimetric index reduces by 8,78%( p<0,0001).  Conclusions. Сhanges morphometric data of young rats under the influence of hypoosmolar  overhydration  are characterized by a uniform increase in the mass of all chambers of the heart and the preferential expansion of the cavity of the right ventricle.  References:  1. Avtandilov G.G.  Fundamentals of quantitative pathological anatomy / G.G. Avtandilov - M.: Medicine, 2002. - 240 p.          2. Hanonh V.F.  Human Physiology / William F. Hanonh - Lviv, 2002. - P.669-678 .  3. Methods of experimental reproduction of fluid and electrolyte disorders / V.Z. Sikora, G.F. Tkach , V.I. Bumeyster [ et al. ] / Proceedings of the conference "The morphological state of tissues and organs of the body in health and disease", Ternopil 10-11th of June 2009, P. 160-161 .  Yarmolenko O.S. Analysis of organometric data of myocardium in young rats at water intoxication / O.S. Yarmolenko, V.I. Bumeister // International scientific and practical conference "Perspective trends in scientific research – 2015", 17th - 22th of October 2015: Materials of International scientific and practical conference. – Vol. 2, Bratislava, Slovac Republic. – 2015. – P. 144-145. 

Нами було досліджено зміни органометричних параметрів  серця молодих щурів при гіпоосмолярній гіпергідратації. Вони характеризуються рівномірним збільшенням маси всіх камер серця та переважним розширенням порожнини правого шлуночка.Нами были исследованы изменения органометричних параметров сердца молодых крыс при гипоосмолярной гипергидратации. Они характеризуются равномерным увеличением массы всех камер сердца и преимущественным расширением полости правого желудочка.We studied the changes of organometric parameters of the heart in young rats at hypoosmolar overhydration. They are characterized by a uniform increase in the mass of all chambers of the heart and the preferential expansion of the cavity of the right ventricle

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Analysis of organometric data of myocardium in young rats at water intoxication

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SocioEconomic Challenges Journal (Sumy State University)

Electronic Sumy State University Institutional Repository

Electronic Sumy State University Institutional Repository