Frick, Faculty Advisor, Jeffrey

Sacho, \u2702, Elizabeth J.

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Illinois Wesleyan UniversityDigital Commons @ IWUJohn Wesley Powell Student ResearchConference 2002, 13th Annual JWP ConferenceApr 21st, 1:15 PM - 2:15 PMSynthesis of Oxazolidinones via a Bicyclic AziridineIntermediateElizabeth J. Sacho, '02Illinois Wesleyan UniversityJeffrey Frick, Faculty AdvisorIllinois Wesleyan UniversityFollow this and additional works at: http://digitalcommons.iwu.edu/jwprcThis Event is brought to you for free and open access by The Ames Library, the Andrew W. Mellon Center for Curricular and FacultyDevelopment, the Office of the Provost and the Office of the President. It has been accepted for inclusion in Digital Commons @ IWU bythe faculty at Illinois Wesleyan University. For more information, please contact digitalcommons@iwu.edu.©Copyright is owned by the author of this document.Elizabeth J. Sacho, '02 and Jeffrey Frick, Faculty Advisor, "Synthesis of Oxazolidinones via a Bicyclic AziridineIntermediate" (April 21, 2002). John Wesley Powell Student Research Conference. Paper 15.http://digitalcommons.iwu.edu/jwprc/2002/posters3/15Poster Presentation P24 SYNTHESIS OF OXAZOLIDINONES VIA A BICYCLIC AZIRIDINE INTERMEDIATE Elizabeth J. Sacho and Jeffrey Frick* Department of Chemistry, Illinois Wesleyan University Oxazolidinones have been shown to have antibacterial activity, and are being further developed for use in biological systems. The focus of my research has been on the synthesis of oxazolidinones through a bicyclic aziridine intermediate. Thermolysis reaction of an azidoformate yields the bicyclic aziridine. Reacting the bicyclic aziridine with various carboxylic acids forms the various oxazolidinones. I� TI _i'> O� I Sh \ F\ TrO� . oA R-COOHll> J-{NH TrO -C --R  � 

Synthesis of Oxazolidinones via a Bicyclic Aziridine Intermediate

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Synthesis of Oxazolidinones via a Bicyclic Aziridine Intermediate

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