Banks, Teresa

Becker, Benjamin

Fairall, Josephine

Hartman, Sarah

Haury, Elise

Sloan, Kelli

Tesler, Scott

Thomas, Kathryn

Tinkler, Faculty Advisor, Gregory

Wodka, Malory

Digital Commons @ Illinois Wesleyan University

Illinois Wesleyan UniversityDigital Commons @ IWUJohn Wesley Powell Student ResearchConference 2012, 23rd Annual JWP ConferenceApr 14th, 9:00 AM - 10:00 AMEffects of Allopregnanolone on Object and SpatialLearningSarah HartmanIllinois Wesleyan UniversityTeresa BanksIllinois Wesleyan UniversityBenjamin BeckerIllinois Wesleyan UniversityJosephine FairallIllinois Wesleyan UniversityElise HauryIllinois Wesleyan UniversitySee next page for additional authorsFollow this and additional works at: http://digitalcommons.iwu.edu/jwprcThis Event is brought to you for free and open access by The Ames Library, the Andrew W. Mellon Center for Curricular and FacultyDevelopment, the Office of the Provost and the Office of the President. It has been accepted for inclusion in Digital Commons @ IWU bythe faculty at Illinois Wesleyan University. For more information, please contact digitalcommons@iwu.edu.©Copyright is owned by the author of this document.Sarah Hartman; Teresa Banks; Benjamin Becker; Josephine Fairall; Elise Haury; Kelli Sloan; Scott Tesler; KathrynThomas; Malory Wodka; and Gregory Tinkler, Faculty Advisor, "Effects of Allopregnanolone on Object and SpatialLearning" (April 14, 2012). John Wesley Powell Student Research Conference. Paper 4.http://digitalcommons.iwu.edu/jwprc/2012/posters/4Presenter InformationSarah Hartman; Teresa Banks; Benjamin Becker; Josephine Fairall; Elise Haury; Kelli Sloan; Scott Tesler;Kathryn Thomas; Malory Wodka; and Gregory Tinkler, Faculty AdvisorThis event is available at Digital Commons @ IWU: http://digitalcommons.iwu.edu/jwprc/2012/posters/4THE JOHN WESLEY POWELL STUDENT RESEARCH CONFERENCE – APRIL 2012   Poster Presentation  P7    EFFECTS OF ALLOPREGNANOLONE ON OBJECT AND SPATIAL LEARNING    Sarah B. Hartman, Teresa Banks, Benjamin Becker, Josephine Fairall, Elise Haury, Kelli Sloan, Scott Tesler, Kathryn Thomas, Malory Wodka, and Gregory P. Tinkler, Ph.D*. Department of Psychology, Illinois Wesleyan University    Allopregnanolone (Allo) is a neurosteroid metabolite of progesterone.  Allo modulates cognition, specifically learning and memory, but these effects are frequently confounded by its anxiolytic properties.  We attempted to dissociate the anxiolytic effects of Allo from its mnemonic effects using a subthreshold pharmacological challenge with the stimulant d-amphetamine.  We assessed both spatial and nonspatial memory.  Spatial memory was tested in a Morris Water Maze, and nonspatial object memory was tested on a novel discrimination task.  Allo, alone or in combination with d-amphetamine did not have any significant effects on spatial memory.  Both Allo and amphetamine impaired novel object performance, but the combination of the two enhanced performance.  The results suggest that, depending on the cognitive domain being tested, the sedative effects of Allo can be dissociated from mnemonic effects.        

Effects of Allopregnanolone on Object and Spatial Learning

http://digitalcommons.iwu.edu/cgi/viewcontent.cgi?article=2850&context=jwprc

Effects of Allopregnanolone on Object and Spatial Learning

Abstract

Similar works

Full text

Available Versions

Digital Commons @ Illinois Wesleyan University