Bond, Steven M

Dornan, Faculty Advisor, Wayne A

Digital Commons @ Illinois Wesleyan University

Illinois Wesleyan UniversityDigital Commons @ IWUJohn Wesley Powell Student ResearchConference 1994, 5th Annual JWP ConferenceApr 23rd, 9:00 AM - 4:00 PMToward an Understanding of Alzheimer's DiseaseVI: A Comparison of the Effects of BilateralInjections of βA (1-42) and βA (25-35) intoHippocampus on the Acquisition of a Spatial Taskin the Male RatSteven M. BondIllinois Wesleyan UniversityWayne A. Dornan, Faculty AdvisorIllinois Wesleyan UniversityFollow this and additional works at: http://digitalcommons.iwu.edu/jwprcThis Event is brought to you for free and open access by The Ames Library, the Andrew W. Mellon Center for Curricular and FacultyDevelopment, the Office of the Provost and the Office of the President. It has been accepted for inclusion in Digital Commons @ IWU bythe faculty at Illinois Wesleyan University. For more information, please contact digitalcommons@iwu.edu.©Copyright is owned by the author of this document.Steven M. Bond and Wayne A. Dornan, Faculty Advisor, "Toward an Understanding of Alzheimer's Disease VI: AComparison of the Effects of Bilateral Injections of βA (1-42) and βA (25-35) into Hippocampus on the Acquisition of aSpatial Task in the Male Rat" (April 23, 1994). John Wesley Powell Student Research Conference. Paper 9.http://digitalcommons.iwu.edu/jwprc/1994/posters/9TOWARD AN UNDERSTANDING OF ALZHEIMER'S DISEASE VI: A COMPARISON OF THE EFFECTS OF BILATERAL INJECTIONS OF J3A (1-42) AND J3A (25-35) INTO HIPPOCAMPUS ON THE ACQUISITION OF A SPATIAL TASK IN THE MALE RAT Steven M. Bond and Wayne A. Dornan*, Department of Psych010gy, IWU Alzheimer's disease (AD) is a neurodegenerative condition which presently affects more than 4 million Americans. Cognitive1y, AD manifests itself through gradual memory loss, learning disruption, and dementia. The neuropathology of AD is not completely understood though it is generally agreed that the neurons of the hippocampus are among the neuroanatomical structures selectively targeted in the disease. Extracellular neuritic plaques and intracellular neurofibrillary tangles have been identified as characteristic neurohistological features that may play a role in AD etiology. Accumulating evidence suggests that the aggregation of the 39-43 amino acid protein, beta amyloid (J3A) , may exhibit neurotoxicity either individually or synergistically with excitotoxins in the brain. Dornan, Kang, McCampbell, and Kang (Neuroreport, 1993) reported that bilateral injections of J3A (25-35) in combination with a subthreshold dose of ibotenic acid (IBO) produced a dramatic disruption in acquisition of spatial learning in the rat. This deficit was accompanied by cell death in the hippocampus that mimicked the degeneration observed in AD. In that study, however, injections of J3A (25-35) alone had no effect on the acquisition of spatial learning. At present, whether fragments of J3A or the full protein produce neurotoxicity in neurons remains somewhat controversial. Therefore, in this study the effects of bilateral injections into the hippocampus of J3A (1-42) on the acquisition of spatial learning in the rat were compared with J3A (25-35), saline, and a subthreshold dose of ibotenic acid. Comparisons were made using a partially baited 8-arm radial arm maze. To assess the effects of these injections on spatial learning, the following parameters were recorded: session latency, latency to first choice, total number of choices, total correct choices, reference memory errors, working memory correct and incorrect errors, and choice accuracy. The results of this study will be presented at the conference. 

Toward an Understanding of Alzheimer\u27s Disease VI: A Comparison of the Effects of Bilateral Injections of βA (1-42) and βA (25-35) into Hippocampus on the Acquisition of a Spatial Task in the Male Rat

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Toward an Understanding of Alzheimer\u27s Disease VI: A Comparison of the Effects of Bilateral Injections of βA (1-42) and βA (25-35) into Hippocampus on the Acquisition of a Spatial Task in the Male Rat

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