Balser, Faculty Advisor, Elizabeth

Chae, HeeDon

Gu, Yi

Lee, Katherine

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Illinois Wesleyan UniversityDigital Commons @ IWUJohn Wesley Powell Student ResearchConference 2006, 17th Annual JWP ConferenceApr 8th, 2:35 PM - 3:35 PMCross-Talk Between RHO GTPases RegulatesActin Cytoskeleton and Cell MovementKatherine LeeIllinois Wesleyan UniversityHeeDon ChaeIllinois Wesleyan UniversityYi GuIllinois Wesleyan UniversityElizabeth Balser, Faculty AdvisorIllinois Wesleyan UniversityFollow this and additional works at: http://digitalcommons.iwu.edu/jwprcThis Event is brought to you for free and open access by The Ames Library, the Andrew W. Mellon Center for Curricular and FacultyDevelopment, the Office of the Provost and the Office of the President. It has been accepted for inclusion in Digital Commons @ IWU bythe faculty at Illinois Wesleyan University. For more information, please contact digitalcommons@iwu.edu.©Copyright is owned by the author of this document.Katherine Lee; HeeDon Chae; Yi Gu; and Elizabeth Balser, Faculty Advisor, "Cross-Talk Between RHO GTPasesRegulates Actin Cytoskeleton and Cell Movement" (April 8, 2006). John Wesley Powell Student Research Conference.Paper 20.http://digitalcommons.iwu.edu/jwprc/2006/posters2/20THE JOHN WESLEY POWELL STUDENT RESEARCH CONFERENCE - APRIL 2006 Poster Presentation P42 CROSS-TALK BETWEEN RHO GTPASES REGULATES ACTIN CYTOSKELETON AND CELL MOVEMENT Katherine Lee and HeeDon Chae. and Yi Gu and Elizabeth Balser* Biology Department, Illinois Wesleyan University Division of Experimental Hematology, Cincinnati Children's Hospital Medical Center Guanosine triphosphatases (GTPases) are small enzymatic proteins associated with the plasma membrane that are important in cell movement and proliferation. RhoH is a unique. GTPase because it is exclusive to hematopoietic stem cells (precursors of all blood cells) and because, unlike many GTPases, it does not cycle between active and inactive states. These two characteristics directed our study of RhoH and its interaction with two additional GTPases, Rac1 & 2.  Our studies show that RhoH can block the activity of Rac 1 & 2 in regulation of cytoskeleton formation and cell movement, as seen in cell division. We identified specific portions of the RhoH gene sequence responsible for its localization and activity, allowing for mutation studies. RhoH is found in cells that precede blood cells, and it has important implications for bone marrow transplants and gene therapy treatments. Future studies will continue to characterize the actions of RhoH through interactions with additional proteins in the signaling process. 

Cross-Talk Between RHO GTPases Regulates Actin Cytoskeleton and Cell Movement

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Cross-Talk Between RHO GTPases Regulates Actin Cytoskeleton and Cell Movement

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