Dornan, Faculty Advisor, Wayne A

Tinkler, Gregory P

Digital Commons @ Illinois Wesleyan University

Illinois Wesleyan UniversityDigital Commons @ IWUJohn Wesley Powell Student ResearchConference 1997, 8th Annual JWP ConferenceApr 12th, 9:00 AM - 10:30 AMDeveloping an Animal Model of Alzeheimer'sDisease: Multiple Hippocampal Injections of Beta-Amyloid (1-42) and the Effects on Spatial Learningand Memory in the Male RatGregory P. TinklerIllinois Wesleyan UniversityWayne A. Dornan, Faculty AdvisorIllinois Wesleyan UniversityFollow this and additional works at: http://digitalcommons.iwu.edu/jwprcThis Event is brought to you for free and open access by The Ames Library, the Andrew W. Mellon Center for Curricular and FacultyDevelopment, the Office of the Provost and the Office of the President. It has been accepted for inclusion in Digital Commons @ IWU bythe faculty at Illinois Wesleyan University. For more information, please contact digitalcommons@iwu.edu.©Copyright is owned by the author of this document.Gregory P. Tinkler and Wayne A. Dornan, Faculty Advisor, "Developing an Animal Model of Alzeheimer's Disease:Multiple Hippocampal Injections of Beta-Amyloid (1-42) and the Effects on Spatial Learning and Memory in the Male Rat"(April 12, 1997). John Wesley Powell Student Research Conference. Paper 25.http://digitalcommons.iwu.edu/jwprc/1997/posters/25Poster Presentation 23 DEVELOPING AN ANIMAL MODEL OF ALZEHEIMER'S DISEASE: MULTIPLE IDPPOCAMPAL INJECTIONS OF BETA�AMYLOID (l�42) AND THE EFFECTS ON SPATIAL LEARNING AND MEMORY IN THE MALE RAT. Gregory P. Tinkler and Wayne A. Dornan*, Department of Psychology, IWU Alzheimer's Disease (AD) is a neurodegenerative disorder which affects approximately four million people in the United States alone. A diagnosis of AD can be made only by performing a postmortem examination of the brain and confirming the presence of high numbers of neuritic plaques and neurofibrillary tangles, the pathological hallmarks of the disease. The neuritic plaque is composed primarily of the 39- to 43- amino acid protein B­Amyloid (BA), and is found in large quantities in structures such as the hippocampus, which is intimately involved with learning and memory. BA has been hypothesized to play a role in the onset of AD, but studies which attempt to model the disease using single injections of the peptide fail to produce consistent behavioral impairments. A number of recent studies have suggested that chronic administration of BA or one of its fragments may be more pathologically relevant to AD than single injections, and may also produce more consistent impairments of spatial learning and memory. In addition, our lab has demonstrated that multiple injections of the neurotoxic fragment BA (25-35) into the septum, which projects to the hippocampus, produce a marginal impairment on a spatial task. A marginal depletion of cholinergic markers in the hippocampus was also produced. Since the BA fragment has different chemical properties than the full length peptide, it is conceivable that more profound behavioral and neurochemical impairments may result from the use of BA (1-42). It is also possible that injections into the hippocampus instead of the septum would produce a greater impairment on learning and memory. Therefore, this study examines the effects of multiple hippocampal injections of the full length BA (1-42) peptide on spatial learning and memory in the rat. 

Developing an Animal Model of Alzeheimer\u27s Disease: Multiple Hippocampal Injections of Beta-Amyloid (1-42) and the Effects on Spatial Learning and Memory in the Male Rat

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Developing an Animal Model of Alzeheimer\u27s Disease: Multiple Hippocampal Injections of Beta-Amyloid (1-42) and the Effects on Spatial Learning and Memory in the Male Rat

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