Staphylococci are natural inhabitant of human and animal skin but sometimes they can cause infections affecting many organs (endocarditis, toxic shock syndrome, sepsis, pneumonia and arthritis). Most staphylococci are responsible for skin infections such as boil, carbuncle, and furuncle and some cause food poisoning resulting in severe vomiting and diarrhea. Staphylococci also cause mastitis in cow and also cause joint infection leading to edema and arthritis. An emerging problem in treating S. aureus infections is the increasing resistance against antibiotics

Nazbar, E.

Shubin, P.

SocioEconomic Challenges Journal (Sumy State University)

 3  
МІНІСТЕРСТВО ОСВІТИ ТА НАУКИ УКРАЇНИ 
СУМСЬКИЙ ДЕРЖАВНИЙ УНІВЕРСИТЕТ 
МЕДИЧНИЙ ІНСТИТУТ 
 
 
 
 
АКТУАЛЬНІ ПИТАННЯ 
ТЕОРЕТИЧНОЇ ТА КЛІНІЧНОЇ МЕДИЦИНИ 
Topical Issues of Theoretical and Clinical Medicine 
 
 
 
 
 
ЗБІРНИК ТЕЗ ДОПОВІДЕЙ 
V Міжнародної науково-практичної конференції студентів та молодих вчених 
(м. Суми, 20-21 квітня 2017 року) 
 
 
 
Суми 
Сумський державний університет 
2017 
 
 
156 АКТУАЛЬНІ ПИТАННЯ ТЕОРЕТИЧНОЇ ТА КЛІНІЧНОЇ МЕДИЦИНИ 
Each respondent eat dairy everyday, but 33% of 18 y.o. 30.5% of 19 y.o. 14% of 20 y.o. and 
20% of 21 y.o. don’t eat the fish at all. 
It is noticed, that 60% of students have in their ration a fast-food such as snacks, porridges and 
soups of instant preparation and street food. There are 44.4% of 18 years old, 66.7% - 19 y.o., 52.7% 
of 20 y.o., 70% of 21 y.o. It is defined, that the females eat more fast-food (33% of 60%), herewith 
the maximal using is among 19 y.o. girls. 
 
 
THE PROBLEM OF PROLIFERATION METHICILLIN-RESISTANT S. AUREUS 
Shubin P. PhD student, Nazbar E., student 
Scientific supervisor - Doctor of veterinary sciences, prof. O.Berhilevych 
Sumy State University, Department of Public Health 
Staphylococci are natural inhabitant of human and animal skin but sometimes they can cause 
infections affecting many organs (endocarditis, toxic shock syndrome, sepsis, pneumonia and 
arthritis). Most staphylococci are responsible for skin infections such as boil, carbuncle, and furuncle 
and some cause food poisoning resulting in severe vomiting and diarrhea. Staphylococci also cause 
mastitis in cow and also cause joint infection leading to edema and arthritis. An emerging problem in 
treating S. aureus infections is the increasing resistance against antibiotics.  
The aim of this study was to characterize problem of S. aureus antimicrobial resistance. 
Some staphylococci and in particular S. aureus is methicillin-resistant (MRSA): hospital 
associated (HA-MRSA) or community associated (CA-MRSA), livestock associated (LA-MRSA). 
Infections caused by these resistant strains may be fatal because of lack of alternative antibiotics. 
MRSA are also frequently resistant to most of the commonly used antimicrobial agents, including the 
aminoglycosides, macrolides, chloramphenicol, tetracycline, and fluoroquinolones. MRSA strains 
should be considered to be resistant to all cephalosporins, cephems, and other beta-lactams (such as 
ampicillin-sulbactam, amoxicillin-clavulanic acid, ticarcillin-clavulanic acid, piperacillin-
tazobactam, and the carbapenems). 
MRSA produces large numbers of extracellular proteins and toxins. The most important toxins 
are called Staphylococcal enterotoxins (SEs). There are 17 major serologically distinct SEs (SEA 
through SER with no SEF). In addition, the SEC has three antigenically distinct subtypes: SEC1, 
SEC2, SEC3, and SEG have a variant form called, SEGv. Many SEs are responsible for food 
poisoning, acute illness, fever, erythematous lesions, and hypotension. Enterotoxins are called 
superantigens, because they form a complex with MHC Class II molecules, activating T-cells to 
produce excess amounts of cytokines that contribute to diarrhea and fatal toxic shock syndrome.  
S. aureus and MRSA evolve and adapt the changing environment. Therefore, dissemination of 
MRSA should be continuously monitored for the antibiotic susceptibility pattern and molecular 
epidemiology comprising hospital, community, and livestock settings. 
 
 
 
PECULIARITIES OF CHITOSAN MODIFICATION IN ORDER TO USE AS ANTIDOTE-
THERAPEUTIC AGENT 
1A.M. Sklyar, 2I.Yu. Vysotsky, 2A.A. Kachanova, 2I.V. Lyubchak, 3rd  year student 
1Sumy State A.S. Makarenko Pedagogical University, Department of Chemistry and Methods of 
Chemistry Education 
2Sumy State University, Department of Biophysics, Biochemistry, Pharmacology, and Biomolecular 
Engineering 
Perspective of chitosan’ use as antidote-therapeutic agent at acute intoxications by epoxide 
compounds is high interest, because different xenobiotics containing epoxy groups can interact with 
functional groups of proteins with their inactivation. 


The problem of proliferation methicillin-resistant S. aureus

Electronic Sumy State University Institutional Repository

 3  МІНІСТЕРСТВО ОСВІТИ ТА НАУКИ УКРАЇНИ СУМСЬКИЙ ДЕРЖАВНИЙ УНІВЕРСИТЕТ МЕДИЧНИЙ ІНСТИТУТ     АКТУАЛЬНІ ПИТАННЯ ТЕОРЕТИЧНОЇ ТА КЛІНІЧНОЇ МЕДИЦИНИ Topical Issues of Theoretical and Clinical Medicine      ЗБІРНИК ТЕЗ ДОПОВІДЕЙ V Міжнародної науково-практичної конференції студентів та молодих вчених (м. Суми, 20-21 квітня 2017 року)    Суми Сумський державний університет 2017   156 АКТУАЛЬНІ ПИТАННЯ ТЕОРЕТИЧНОЇ ТА КЛІНІЧНОЇ МЕДИЦИНИ Each respondent eat dairy everyday, but 33% of 18 y.o. 30.5% of 19 y.o. 14% of 20 y.o. and 20% of 21 y.o. don’t eat the fish at all. It is noticed, that 60% of students have in their ration a fast-food such as snacks, porridges and soups of instant preparation and street food. There are 44.4% of 18 years old, 66.7% - 19 y.o., 52.7% of 20 y.o., 70% of 21 y.o. It is defined, that the females eat more fast-food (33% of 60%), herewith the maximal using is among 19 y.o. girls.   THE PROBLEM OF PROLIFERATION METHICILLIN-RESISTANT S. AUREUS Shubin P. PhD student, Nazbar E., student Scientific supervisor - Doctor of veterinary sciences, prof. O.Berhilevych Sumy State University, Department of Public Health Staphylococci are natural inhabitant of human and animal skin but sometimes they can cause infections affecting many organs (endocarditis, toxic shock syndrome, sepsis, pneumonia and arthritis). Most staphylococci are responsible for skin infections such as boil, carbuncle, and furuncle and some cause food poisoning resulting in severe vomiting and diarrhea. Staphylococci also cause mastitis in cow and also cause joint infection leading to edema and arthritis. An emerging problem in treating S. aureus infections is the increasing resistance against antibiotics.  The aim of this study was to characterize problem of S. aureus antimicrobial resistance. Some staphylococci and in particular S. aureus is methicillin-resistant (MRSA): hospital associated (HA-MRSA) or community associated (CA-MRSA), livestock associated (LA-MRSA). Infections caused by these resistant strains may be fatal because of lack of alternative antibiotics. MRSA are also frequently resistant to most of the commonly used antimicrobial agents, including the aminoglycosides, macrolides, chloramphenicol, tetracycline, and fluoroquinolones. MRSA strains should be considered to be resistant to all cephalosporins, cephems, and other beta-lactams (such as ampicillin-sulbactam, amoxicillin-clavulanic acid, ticarcillin-clavulanic acid, piperacillin-tazobactam, and the carbapenems). MRSA produces large numbers of extracellular proteins and toxins. The most important toxins are called Staphylococcal enterotoxins (SEs). There are 17 major serologically distinct SEs (SEA through SER with no SEF). In addition, the SEC has three antigenically distinct subtypes: SEC1, SEC2, SEC3, and SEG have a variant form called, SEGv. Many SEs are responsible for food poisoning, acute illness, fever, erythematous lesions, and hypotension. Enterotoxins are called superantigens, because they form a complex with MHC Class II molecules, activating T-cells to produce excess amounts of cytokines that contribute to diarrhea and fatal toxic shock syndrome.  S. aureus and MRSA evolve and adapt the changing environment. Therefore, dissemination of MRSA should be continuously monitored for the antibiotic susceptibility pattern and molecular epidemiology comprising hospital, community, and livestock settings.    PECULIARITIES OF CHITOSAN MODIFICATION IN ORDER TO USE AS ANTIDOTE-THERAPEUTIC AGENT 1A.M. Sklyar, 2I.Yu. Vysotsky, 2A.A. Kachanova, 2I.V. Lyubchak, 3rd  year student 1Sumy State A.S. Makarenko Pedagogical University, Department of Chemistry and Methods of Chemistry Education 2Sumy State University, Department of Biophysics, Biochemistry, Pharmacology, and Biomolecular Engineering Perspective of chitosan’ use as antidote-therapeutic agent at acute intoxications by epoxide compounds is high interest, because different xenobiotics containing epoxy groups can interact with functional groups of proteins with their inactivation. 

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The problem of proliferation methicillin-resistant S. aureus

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