Thyroid dysfunction is associated with dyslipidemia, a well-known cardiovascular risk factor. Besides dyslipidemia, thyroid dysfunction can induce insulin resistance, hypertension, endothelial dysfunction.  Study objectives: to determine prevalence of hyperuricemia and association with lipid profile in patients with hypothyroidism

Chukwunonso, Arinze

Obinna, Nwokiea Chukwuma

Electronic Sumy State University Institutional Repository

 3  Міністерство освіти та науки України Сумський державний університет Медичний інституту          АКТУАЛЬНІ ПИТАННЯ ТЕРЕТИЧНОЇ ТА ПРАКТИЧНОЇ МЕДИЦИНИ  Topical Issues of Clinical and Theoretical Medicine     Збірник тез доповідей  ІV Міжнародної науково-практичної конференції Студентів та молодих вчених (Суми, 21-22 квітня 2016 року)    ТОМ 2   Суми Сумський державний університет 2016    138 СЕКЦІЯ «ВНУТРІШНЬОЇ МЕДИЦИНИ» the 50 % of persons and the second stage of it is presented also for the 50 % of participants  from the II group. There was no connection between stage of obesity, OH and the levels of UA. Conclusions. In our clinical trial we determined the absence of interrelation between stage of obesity, stage of OH and the levels of UA. Even primary changes of metabolism stimulate the appearance and development the symptoms of OH. The higher levels of UA, AI, stage of obesity we determined for patients with OH.       HYPERURICEMIA AS CARDIOVASCULAR RISK FACTOR IN PATIENTS WITH HYPOTHYROIDISM Chukwunonso Arinze, Obinna Nwokiea Chukwuma Scientific adviser – G.A. Fadieieva, MD Sumy State University, Department of Internal Medicine postgraduate education Thyroid dysfunction is associated with dyslipidemia, a well-known cardiovascular risk factor. Besides dyslipidemia, thyroid dysfunction can induce insulin resistance, hypertension, endothelial dysfunction.  Study objectives: to determine prevalence of hyperuricemia and association with lipid profile in patients with hypothyroidism. Methods:  The study included 58 patients with hypothyroidism and a control group of 20 healthy euthyroid volunteers. The following measurements were made in all participants: thyroid-stimulating hormone (TSH), free thyroxin (FT4) concentration, thyroid peroxidase antibodies, total cholesterol (TC), low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, triglycerides (TG), uric acid. The 1st group included 47 patients with hypothyroidism and normal serum uric acid level, the IInd group – 11 hypothyroid patients with hyperuricemia. Hypothyroidism was defined as a TSH > 4.0 mU/L with a decreased free T4 level, hyperuricemia – serum uric acid > 420 µmol/l for men and >360 µmol/l for women. Results: The mean age of patients was 66.3±3.25 years. Prevalence of hyperuricemia in hypothyroidism is 18,9%. Patients from the 1st group had total cholesterol (5.4±0.77) mmol/l, LDL-cholesterol (3.5±0.45) mmol/l, triglycerides (2.0±0.28) mmol/l. Hyperuricemia in hypothyroid patients from the 2nd group is accompanied by more elevated total cholesterol concentrations (6.7±0.83) mmol/l (p<0.05), LDL cholesterol (4.3±0.63) mmol/l (p<0.05), triglyceride (2.4±0.32 mmol/l). Conclusion: In case of hyperuricemia patients with hypothyroidism have more pronounced changes in atherogenic lipid profile that require special attention in practical medicine.  ATHEROSCLEROSIS PROGRESSION FOR PATIENTS WITH TYPE 2 DIABETES MELLITUS AND DYSLIPIDEMIA Efremova O.A., Demikhova N.V.*, Bamisile Adebayo (group 119)* Belgorod State University, RF; Sumy State University*, Ukraine The main cause of death for patients with diabetes mellitus (DM) in Europe is connected with cardiovascular diseases. There is the correlation between them and hyperglycemia. Aim. To diagnose atherosclerosis in early stages, to develop measures for prevention its progression for patients with type 2 DM and dyslipidemia.  Materials. Study involved 61 patients with type 2DM. They were divided into 2 groups. Group 1 (30) - (22 – with defragment intima and media thickening, 8 – with formed atherosclerotic plaques without changes of vessel diameter), group 2 (31) – with qualitative changes of intima media complex (IMC) (19 people - defragmentation intima and media thickening, 12 – with atherosclerotic plaques without changes the diameter of the vessel). Combined therapy included 20 mg of atorvastatin. The clinical picture was confirmed by the level of HbA1c <7%. For determination the features of atherosclerosis we used complex clinical, laboratory and instrumental methods, including daily monitoring of blood glucose; definition of glycated hemoglobin 

Hyperuricemia as cardiovascular risk factor in patients with hypothyroidism

SocioEconomic Challenges Journal (Sumy State University)

 3  
Міністерство освіти та науки України 
Сумський державний університет 
Медичний інституту 
 
 
 
 
 
 
 
 
 
АКТУАЛЬНІ ПИТАННЯ ТЕРЕТИЧНОЇ ТА 
ПРАКТИЧНОЇ МЕДИЦИНИ 
 
Topical Issues of Clinical and Theoretical 
Medicine 
 
 
 
 
Збірник тез доповідей  
ІV Міжнародної науково-практичної конференції 
Студентів та молодих вчених 
(Суми, 21-22 квітня 2016 року) 
 
 
 
ТОМ 2 
 
 
Суми 
Сумський державний університет 
2016 
  
 138 СЕКЦІЯ «ВНУТРІШНЬОЇ МЕДИЦИНИ» 
the 50 % of persons and the second stage of it is presented also for the 50 % of participants  from 
the II group. There was no connection between stage of obesity, OH and the levels of UA. 
Conclusions. In our clinical trial we determined the absence of interrelation between stage of 
obesity, stage of OH and the levels of UA. Even primary changes of metabolism stimulate the 
appearance and development the symptoms of OH. The higher levels of UA, AI, stage of obesity 
we determined for patients with OH.     
 
 
HYPERURICEMIA AS CARDIOVASCULAR RISK FACTOR IN PATIENTS WITH 
HYPOTHYROIDISM 
Chukwunonso Arinze, Obinna Nwokiea Chukwuma 
Scientific adviser – G.A. Fadieieva, MD 
Sumy State University, Department of Internal Medicine postgraduate education 
Thyroid dysfunction is associated with dyslipidemia, a well-known cardiovascular risk factor. 
Besides dyslipidemia, thyroid dysfunction can induce insulin resistance, hypertension, endothelial 
dysfunction.  
Study objectives: to determine prevalence of hyperuricemia and association with lipid profile 
in patients with hypothyroidism. 
Methods:  The study included 58 patients with hypothyroidism and a control group of 20 
healthy euthyroid volunteers. The following measurements were made in all participants: thyroid-
stimulating hormone (TSH), free thyroxin (FT4) concentration, thyroid peroxidase antibodies, total 
cholesterol (TC), low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) 
cholesterol, triglycerides (TG), uric acid. The 1
st
 group included 47 patients with hypothyroidism 
and normal serum uric acid level, the II
nd
 group – 11 hypothyroid patients with hyperuricemia. 
Hypothyroidism was defined as a TSH > 4.0 mU/L with a decreased free T4 level, hyperuricemia – 
serum uric acid > 420 µmol/l for men and >360 µmol/l for women. 
Results: The mean age of patients was 66.3±3.25 years. Prevalence of hyperuricemia in 
hypothyroidism is 18,9%. 
Patients from the 1
st
 group had total cholesterol (5.4±0.77) mmol/l, LDL-cholesterol 
(3.5±0.45) mmol/l, triglycerides (2.0±0.28) mmol/l. 
Hyperuricemia in hypothyroid patients from the 2
nd
 group is accompanied by more elevated 
total cholesterol concentrations (6.7±0.83) mmol/l (p<0.05), LDL cholesterol (4.3±0.63) mmol/l 
(p<0.05), triglyceride (2.4±0.32 mmol/l). 
Conclusion: In case of hyperuricemia patients with hypothyroidism have more pronounced 
changes in atherogenic lipid profile that require special attention in practical medicine. 
 
ATHEROSCLEROSIS PROGRESSION FOR PATIENTS WITH TYPE 2 DIABETES 
MELLITUS AND DYSLIPIDEMIA 
Efremova O.A., Demikhova N.V.*, Bamisile Adebayo (group 119)* 
Belgorod State University, RF; Sumy State University*, Ukraine 
The main cause of death for patients with diabetes mellitus (DM) in Europe is connected 
with cardiovascular diseases. There is the correlation between them and hyperglycemia. 
Aim. To diagnose atherosclerosis in early stages, to develop measures for prevention its 
progression for patients with type 2 DM and dyslipidemia.  
Materials. Study involved 61 patients with type 2DM. They were divided into 2 groups. 
Group 1 (30) - (22 – with defragment intima and media thickening, 8 – with formed atherosclerotic 
plaques without changes of vessel diameter), group 2 (31) – with qualitative changes of intima 
media complex (IMC) (19 people - defragmentation intima and media thickening, 12 – with 
atherosclerotic plaques without changes the diameter of the vessel). Combined therapy included 20 
mg of atorvastatin. The clinical picture was confirmed by the level of HbA1c <7%. For 
determination the features of atherosclerosis we used complex clinical, laboratory and instrumental 
methods, including daily monitoring of blood glucose; definition of glycated hemoglobin 


English

https://essuir.sumdu.edu.ua/bitstream/123456789/47829/1/Chukwunonso_Hypothyroidism.pdf

Hyperuricemia as cardiovascular risk factor in patients with hypothyroidism

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