Current evidence suggests that prolonged treatment with progesterone and 17 α-
hydroxyprogesterone caproate (17OHPC) may reduce the incidence of premature delivery in high risk patients with a history of spontaneous preterm birth or with a short cervix but failed to understand the mechanism on myometrium

Barbar, T.V.

Nwokiea, Obinna

Electronic Sumy State University Institutional Repository

 3  Міністерство освіти та науки України Сумський державний університет Медичний інституту          АКТУАЛЬНІ ПИТАННЯ ТЕРЕТИЧНОЇ ТА ПРАКТИЧНОЇ МЕДИЦИНИ  Topical Issues of Clinical and Theoretical Medicine     Збірник тез доповідей  ІV Міжнародної науково-практичної конференції Студентів та молодих вчених (Суми, 21-22 квітня 2016 року)    ТОМ 2   Суми Сумський державний університет 2016    327 СЕКЦІЯ «ХІРУРГІЯ» Выводы. Открытые оперативные вмешательства занимают главенствующую роль в лечении КН. На их долю приходится 55,2% от всех вмешательств, 44,8% занимают малоинвазивные методы.   PROGESTERONE MYOMETRIAL EFFECT AND MECHANISM FOR THE PREVENTION OF PRETERM BIRTH Dr Barbar .T. V.,  Nwokiea Obinna, Sumy state university, medical institute, department of  obstetrics and gyneocology          Current evidence suggests that prolonged treatment with progesterone and 17 α-hydroxyprogesterone caproate (17OHPC) may reduce the incidence of premature delivery in high risk patients with a history of spontaneous preterm birth  or with a short cervix but failed to understand the mechanism on myometrium.            We studied the progesterone mechanism for the prevention of preterm birth in high risk patient with short cervix and recurrent preterm birth by our hypothesis that progesterone has a direct inhibitory effect on spontaneous myometrium contractility.         We divide the group of pregnant women with recruited highly risk comprises of 75 single pregnant women  of high risk,  20 of them is their first pregnancy but had short cervix,  40 of them had history of spontaneous abortion due to short cervix  and 15 of them had history of spontaneous abortion from other etiologies. 1st group   40  of the women were given  vaginal progesterone,100mg daily  from 24 to 37  weeks of gestation and  2nd group  , the placebo group comprises of    35 of the pregnant women who received placebo.        We used vaginal ultrasound to check for the size of the cervix and also did progesterone clinical analysis based on the symptom of low abdominal pain and ultrasound indication of short cervix.           The result showed that 80% of 40 people in progesterone group had full term labor above 37 weeks and 20 % couldn’t reach full term and had cesarean section ranging from 34th to 37th week and we collected myometrium biopsy on the process. But  90%  had spontaneous abortion for the 2nd group mostly on those with history of short cervix and history of spontaneous abortion.10 % reached full term mostly from group of history of spontaneous preterm abortion of other etiologies and myometrial biopsy was collected on those that had caesarian . Myometrium biopsies which were obtained from the upper border of the lower uterine segment incision during caesarean section the Samples were divided and used for contractility measurements. And we discovered that  progesterone, exerted consistent, rapid and sustained inhibition of the amplitude of spontaneous myometrial contractions in vitro at high concentrations.   INVESTIGATIVE UTILITY OFMICROSATLITE GENOTYPING FOR MOLAR PREGNANCY TESTING Ezugwu Chisom Anthoinette Scientific supervisor: Assistant Department of Obstetrics and Gynecology, Babar T.B Sumy State University, Department of Obstetrics and Gynecology         Hydatidiform  mole also known  as hydatid mole, molar pregnancy, gestational trophoblastic disease is a type of fertilization abnormality, when only the conceptus trophoblast layers proliferates and not the embryoblast, no embryo develops, this is called a  “Hydatidiform mole". Due to the continuing presence of the trophoblastic layer, this abnormal conceptus can also implant in the uterus or ectopically. The trophoblast cells will secrete human chorionic gonadotropin (hCG), as in a normal pregnancy, and may appear maternally and by pregnancy test to be "normal". Prenatal diagnosis by ultrasound analysis demonstrates the absence of an embryo.          There are several forms of hydatidiform mole: partial mole, complete mole, gestational trophoblastic tumor. Many of these tumours arise from a haploid sperm fertilizing an egg without a female pronucleus (the alternative form, an embryo without sperm contribution, is called parthenogenesis). The tumour has a "grape-like" placental appearance without enclosed embryo formation. Following a first molar pregnancy, there is approximately a 1% risk of a second molar pregnancy. The incidence of hydatidiform mole varies between ethnic groups, and typically occurs 

Progesterone myometrial effect and mechanism for the prevention of preterm birth

SocioEconomic Challenges Journal (Sumy State University)

 3  
Міністерство освіти та науки України 
Сумський державний університет 
Медичний інституту 
 
 
 
 
 
 
 
 
 
АКТУАЛЬНІ ПИТАННЯ ТЕРЕТИЧНОЇ ТА 
ПРАКТИЧНОЇ МЕДИЦИНИ 
 
Topical Issues of Clinical and Theoretical 
Medicine 
 
 
 
 
Збірник тез доповідей  
ІV Міжнародної науково-практичної конференції 
Студентів та молодих вчених 
(Суми, 21-22 квітня 2016 року) 
 
 
 
ТОМ 2 
 
 
Суми 
Сумський державний університет 
2016 
  
 327 СЕКЦІЯ «ХІРУРГІЯ» 
Выводы. Открытые оперативные вмешательства занимают главенствующую роль в 
лечении КН. На их долю приходится 55,2% от всех вмешательств, 44,8% занимают 
малоинвазивные методы. 
 
 
PROGESTERONE MYOMETRIAL EFFECT AND MECHANISM FOR THE 
PREVENTION OF PRETERM BIRTH 
Dr Barbar .T. V.,  Nwokiea Obinna, 
Sumy state university, medical institute, department of  obstetrics and gyneocology 
         Current evidence suggests that prolonged treatment with progesterone and 17 α-
hydroxyprogesterone caproate (17OHPC) may reduce the incidence of premature delivery in high 
risk patients with a history of spontaneous preterm birth  or with a short cervix but failed to 
understand the mechanism on myometrium. 
           We studied the progesterone mechanism for the prevention of preterm birth in high risk 
patient with short cervix and recurrent preterm birth by our hypothesis that progesterone has a direct 
inhibitory effect on spontaneous myometrium contractility. 
        We divide the group of pregnant women with recruited highly risk comprises of 75 single 
pregnant women  of high risk,  20 of them is their first pregnancy but had short cervix,  40 of them 
had history of spontaneous abortion due to short cervix  and 15 of them had history of spontaneous 
abortion from other etiologies. 1
st
 group   40  of the women were given  vaginal 
progesterone,100mg daily  from 24 to 37  weeks of gestation and  2
nd
 group  , the placebo group 
comprises of    35 of the pregnant women who received placebo.  
      We used vaginal ultrasound to check for the size of the cervix and also did progesterone clinical 
analysis based on the symptom of low abdominal pain and ultrasound indication of short cervix.  
         The result showed that 80% of 40 people in progesterone group had full term labor above 37 
weeks and 20 % couldn’t reach full term and had cesarean section ranging from 34th to 37th week 
and we collected myometrium biopsy on the process. But  90%  had spontaneous abortion for the 
2
nd
 group mostly on those with history of short cervix and history of spontaneous abortion.10 % 
reached full term mostly from group of history of spontaneous preterm abortion of other etiologies 
and myometrial biopsy was collected on those that had caesarian . Myometrium biopsies which 
were obtained from the upper border of the lower uterine segment incision during caesarean section 
the Samples were divided and used for contractility measurements. And we discovered that  
progesterone, exerted consistent, rapid and sustained inhibition of the amplitude of spontaneous 
myometrial contractions in vitro at high concentrations. 
 
 
INVESTIGATIVE UTILITY OFMICROSATLITE GENOTYPING FOR MOLAR 
PREGNANCY TESTING 
Ezugwu Chisom Anthoinette 
Scientific supervisor: Assistant Department of Obstetrics and Gynecology, Babar T.B 
Sumy State University, Department of Obstetrics and Gynecology 
        Hydatidiform  mole also known  as hydatid mole, molar pregnancy, gestational trophoblastic 
disease is a type of fertilization abnormality, when only the conceptus trophoblast layers proliferates 
and not the embryoblast, no embryo develops, this is called a  “Hydatidiform mole". Due to the 
continuing presence of the trophoblastic layer, this abnormal conceptus can also implant in the 
uterus or ectopically. The trophoblast cells will secrete human chorionic gonadotropin (hCG), as in 
a normal pregnancy, and may appear maternally and by pregnancy test to be "normal". Prenatal 
diagnosis by ultrasound analysis demonstrates the absence of an embryo.   
       There are several forms of hydatidiform mole: partial mole, complete mole, gestational 
trophoblastic tumor. Many of these tumours arise from a haploid sperm fertilizing an egg without a 
female pronucleus (the alternative form, an embryo without sperm contribution, is called 
parthenogenesis). The tumour has a "grape-like" placental appearance without enclosed embryo 
formation. Following a first molar pregnancy, there is approximately a 1% risk of a second molar 
pregnancy. The incidence of hydatidiform mole varies between ethnic groups, and typically occurs 


English

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Progesterone myometrial effect and mechanism for the prevention of preterm birth

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